Are there any theranostic biomarkers in small cell lung carcinoma?
Small cell lung cancer (SCLC)
biomarkers
theranostics
Journal
Journal of thoracic disease
ISSN: 2072-1439
Titre abrégé: J Thorac Dis
Pays: China
ID NLM: 101533916
Informations de publication
Date de publication:
Jan 2019
Jan 2019
Historique:
entrez:
19
2
2019
pubmed:
19
2
2019
medline:
19
2
2019
Statut:
ppublish
Résumé
Small cell lung cancer (SCLC), an aggressive lung tumour with a poor prognosis, has a high load of somatic mutations, mainly induced by tobacco carcinogens given the strong association with smoking. Advances in genomic, epigenetic and proteomic profiling have significantly improved our understanding of the molecular and cellular biology of SCLC. Given the high mutational burden of SCLC the immune microenvironment is another exciting area under investigation even if it seems to be quite distinct from that of other solid tumours. In this review we will outline the current progress in molecular etiology of SCLC mentioning some key markers considered promising theranostic biomarkers.
Identifiants
pubmed: 30775033
doi: 10.21037/jtd.2018.12.14
pii: jtd-11-S1-S102
pmc: PMC6353747
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
S102-S112Déclaration de conflit d'intérêts
Conflict of Interest: The authors have no conflicts of interest to declare.
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