Straightforward Regeneration of Reduced Flavin Adenine Dinucleotide Required for Enzymatic Tryptophan Halogenation.

Journal

ACS catalysis
ISSN: 2155-5435
Titre abrégé: ACS Catal
Pays: United States
ID NLM: 101562209

Informations de publication

Date de publication:
01 Feb 2019
Historique:
received: 08 11 2018
revised: 21 12 2018
entrez: 19 2 2019
pubmed: 19 2 2019
medline: 19 2 2019
Statut: ppublish

Résumé

Flavin-dependent halogenases are known to regioselectively introduce halide substituents into aromatic moieties, for example, the indole ring of tryptophan. The process requires halide salts and oxygen instead of molecular halogen in the chemical halogenation. However, the reduced cofactor flavin adenine dinucleotide (FADH

Identifiants

DOI: 10.1021/acscatal.8b04500 PMID: 30775067 PMC: PMC6369659
pubmed: 30775067
doi: 10.1021/acscatal.8b04500
pmc: PMC6369659
doi:

Types de publication

Journal Article

Langues

eng

Pagination

1389-1395

Déclaration de conflit d'intérêts

The authors declare no competing financial interest.

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Auteurs

Mohamed Ismail (M)

Organic and Bioorganic Chemistry, Department of Chemistry, and Physical and Biophysical Chemistry, Department of Chemistry, Bielefeld University, P.O. Box 100131, 33501 Bielefeld, Germany.
Department of Microbiology, Faculty of Science, Helwan University, Ain Helwan, Helwan, Cairo 11795, Egypt.

Lea Schroeder (L)

Organic and Bioorganic Chemistry, Department of Chemistry, and Physical and Biophysical Chemistry, Department of Chemistry, Bielefeld University, P.O. Box 100131, 33501 Bielefeld, Germany.

Marcel Frese (M)

Organic and Bioorganic Chemistry, Department of Chemistry, and Physical and Biophysical Chemistry, Department of Chemistry, Bielefeld University, P.O. Box 100131, 33501 Bielefeld, Germany.

Tilman Kottke (T)

Organic and Bioorganic Chemistry, Department of Chemistry, and Physical and Biophysical Chemistry, Department of Chemistry, Bielefeld University, P.O. Box 100131, 33501 Bielefeld, Germany.

Frank Hollmann (F)

Department of Biotechnology, Delft University of Technology, van der Maasweg 9, 2629 HZ Delft, The Netherlands.

Caroline E Paul (CE)

Department of Biotechnology, Delft University of Technology, van der Maasweg 9, 2629 HZ Delft, The Netherlands.
Laboratory of Organic Chemistry, Wageningen University & Research, Stippeneng 4, 6708 WE Wageningen, The Netherlands.

Norbert Sewald (N)

Organic and Bioorganic Chemistry, Department of Chemistry, and Physical and Biophysical Chemistry, Department of Chemistry, Bielefeld University, P.O. Box 100131, 33501 Bielefeld, Germany.

Classifications MeSH