Monocyte heterogeneity and functions in cancer.
Monocytes
cancer
myeloid cells
tumor microenvironment
Journal
Journal of leukocyte biology
ISSN: 1938-3673
Titre abrégé: J Leukoc Biol
Pays: England
ID NLM: 8405628
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
07
08
2018
revised:
11
12
2018
accepted:
21
01
2019
pubmed:
19
2
2019
medline:
12
5
2020
entrez:
19
2
2019
Statut:
ppublish
Résumé
Monocytes are innate immune cells of the mononuclear phagocyte system that have emerged as important regulators of cancer development and progression. Our understanding of monocytes has advanced from viewing these cells as a homogenous population to a heterogeneous system of cells that display diverse responses to different stimuli. During cancer, different monocyte subsets perform functions that contribute to both pro- and antitumoral immunity, including phagocytosis, secretion of tumoricidal mediators, promotion of angiogenesis, remodeling of the extracellular matrix, recruitment of lymphocytes, and differentiation into tumor-associated macrophages and dendritic cells. The ability of cancer to evade immune recognition and clearance requires protumoral signals to outweigh ongoing attempts by the host immune system to prevent tumor growth. This review discusses current understanding of monocyte heterogeneity during homeostasis, highlights monocyte functions in cancer progression, and describes monocyte-targeted therapeutic strategies for cancer treatment.
Identifiants
pubmed: 30776148
doi: 10.1002/JLB.4RI0818-311R
pmc: PMC6658332
mid: NIHMS1018369
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
309-322Subventions
Organisme : NCI NIH HHS
ID : R01 CA202987
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL134236
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA224766
Pays : United States
Informations de copyright
©2019 The Authors. Society for Leukocyte Biology Published by Wiley Periodicals, Inc.
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