Unraveling the host's immune response to infection: Seeing is believing.
bacterial infections
innate immunity
intravital microscopy
Journal
Journal of leukocyte biology
ISSN: 1938-3673
Titre abrégé: J Leukoc Biol
Pays: England
ID NLM: 8405628
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
21
12
2018
revised:
25
01
2019
accepted:
29
01
2019
pubmed:
19
2
2019
medline:
12
5
2020
entrez:
19
2
2019
Statut:
ppublish
Résumé
It has long been appreciated that understanding the interactions between the host and the pathogens that make us sick is critical for the prevention and treatment of disease. As antibiotics become increasingly ineffective, targeting the host and specific bacterial evasion mechanisms are becoming novel therapeutic approaches. The technology used to understand host-pathogen interactions has dramatically advanced over the last century. We have moved away from using simple in vitro assays focused on single-cell events to technologies that allow us to observe complex multicellular interactions in real time in live animals. Specifically, intravital microscopy (IVM) has improved our understanding of infection, from viral to bacterial to parasitic, and how the host immune system responds to these infections. Yet, at the same time it has allowed us to appreciate just how complex these interactions are and that current experimental models still have a number of limitations. In this review, we will discuss the advances in vivo IVM has brought to the study of host-pathogen interactions, focusing primarily on bacterial infections and innate immunity.
Identifiants
pubmed: 30776153
doi: 10.1002/JLB.4RI1218-503R
pmc: PMC6849780
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
323-335Informations de copyright
©2019 The Authors. Society for Leukocyte Biology Published by Wiley Periodicals, Inc.
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