Phase II metabolism of betulin by rat and human UDP-glucuronosyltransferases and sulfotransferases.
Betulin
Glucuronidation
Isoenzymes
Sulfation
Journal
Chemico-biological interactions
ISSN: 1872-7786
Titre abrégé: Chem Biol Interact
Pays: Ireland
ID NLM: 0227276
Informations de publication
Date de publication:
01 Apr 2019
01 Apr 2019
Historique:
received:
07
11
2018
revised:
31
01
2019
accepted:
14
02
2019
pubmed:
19
2
2019
medline:
30
3
2019
entrez:
19
2
2019
Statut:
ppublish
Résumé
The natural product betulin is under investigation for several therapeutic indications, however little is known about its metabolism. In the present study, the glucuronidation and sulfation of betulin in human and rat liver microsomes and cytosol were tested. We further identified the main UDP-glucuronosyltransferases (UGTs) and sulfotransferases (SULTs) involved in these two metabolism pathways. Results showed that one betulin glucuronide metabolite was observed after incubation with human and rat liver microsomes. The glucuronidation of betulin in human liver microsomes had a K
Identifiants
pubmed: 30776358
pii: S0009-2797(18)31522-9
doi: 10.1016/j.cbi.2019.02.009
pii:
doi:
Substances chimiques
Protein Isoforms
0
Recombinant Proteins
0
Triterpenes
0
betulin
6W70HN7X7O
Glucuronosyltransferase
EC 2.4.1.17
Sulfotransferases
EC 2.8.2.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
190-195Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.