Oleanolic acid 3-glucoside, a synthetic oleanane-type saponin, alleviates methylmercury toxicity in vitro and in vivo.
Anti-methylmercury activity
Oleanane-type triterpene saponin
Oleanolic acid 3-glucoside
Journal
Toxicology
ISSN: 1879-3185
Titre abrégé: Toxicology
Pays: Ireland
ID NLM: 0361055
Informations de publication
Date de publication:
01 04 2019
01 04 2019
Historique:
received:
03
09
2018
revised:
20
01
2019
accepted:
11
02
2019
pubmed:
19
2
2019
medline:
15
1
2020
entrez:
19
2
2019
Statut:
ppublish
Résumé
Methylmercury (MeHg) is one of the most toxic environmental pollutants, presenting a serious health hazard worldwide. In this study, we examined the potential of derivatives of oleanolic acid (OA), such as OA 3-glucoside, OA 28-glucoside, and OA 3,28-diglucoside, to mitigate MeHg toxicity in vitro and in vivo. We found that OA 3-glucoside suppressed the cellular MeHg uptake by 63.4% compared with that of the control and improved the cell viability from 75.4% to 107.9% upon exposure to cytotoxic MeHg in Caco-2 cells. To verify the anti-MeHg activity of OA 3-glucoside, mice were orally administered MeHg (0, 1.0, or 5.0 mg kg
Identifiants
pubmed: 30776458
pii: S0300-483X(18)30276-2
doi: 10.1016/j.tox.2019.02.006
pii:
doi:
Substances chimiques
Glucosides
0
Methylmercury Compounds
0
Saponins
0
oleanane
0
Oleanolic Acid
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Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
15-22Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.