The influence of tau, amyloid, alpha-synuclein, TDP-43, and vascular pathology in clinically normal elderly individuals.
Aged
Aged, 80 and over
Aging
/ metabolism
Amyloid beta-Peptides
/ metabolism
Apolipoprotein E4
/ metabolism
Blood Vessels
/ pathology
Brain
/ blood supply
Cognition
DNA-Binding Proteins
/ metabolism
Depression
Female
Humans
Male
Memory
Middle Aged
Organ Size
Psychomotor Performance
alpha-Synuclein
/ metabolism
tau Proteins
/ metabolism
Brain volume
Clinically normal aging
Cognition
Depression
Neurodegenerative pathology
TDP-43
Vascular pathology
Journal
Neurobiology of aging
ISSN: 1558-1497
Titre abrégé: Neurobiol Aging
Pays: United States
ID NLM: 8100437
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
19
07
2018
revised:
11
01
2019
accepted:
12
01
2019
pubmed:
19
2
2019
medline:
18
12
2019
entrez:
19
2
2019
Statut:
ppublish
Résumé
Many individuals live to older ages without clinical impairment. It is unknown whether brain pathologies in these individuals are associated with subtle clinical deficits. We analyzed the brains of 161 clinically normal (Clinical Dementia Rating score = 0) older individuals enrolled in the Mayo Clinic Patient Registry or Study of Aging. We assessed for the presence and burden of beta-amyloid, tau, alpha-synuclein, TDP-43, and vascular pathology. We investigated whether pathologies were associated with antemortem cognitive and motor function, depression, MRI volumetric measures, or the apolipoprotein E (APOE) ε4 allele. Eighty-six percent had at least 1 pathology, and 63% had mixed pathologies. Tau and vascular pathology were associated with poorer memory scores. Tau was also associated with poorer general cognition scores and smaller amygdala, hippocampi, and entorhinal cortex volumes. Beta-amyloid neuritic plaque burden was associated with greater depression scores. The presence of a greater number of pathologies was associated with APOE e4 carrier status and with poorer memory performance. Some dementia-related pathologies are associated with poorer performance in clinical measures and brain atrophy in the unimpaired elderly.
Identifiants
pubmed: 30776649
pii: S0197-4580(19)30018-1
doi: 10.1016/j.neurobiolaging.2019.01.008
pmc: PMC6486870
mid: NIHMS1519203
pii:
doi:
Substances chimiques
Amyloid beta-Peptides
0
Apolipoprotein E4
0
DNA-Binding Proteins
0
TARDBP protein, human
0
alpha-Synuclein
0
tau Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
26-36Subventions
Organisme : NIA NIH HHS
ID : R01 AG041851
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG016574
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG037491
Pays : United States
Organisme : NIA NIH HHS
ID : R37 AG011378
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG006786
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.
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