Ferritin in serum and urine: A pilot study.
Ferritin
Iron
Iron deficiency
Serum
Urine
Journal
Blood cells, molecules & diseases
ISSN: 1096-0961
Titre abrégé: Blood Cells Mol Dis
Pays: United States
ID NLM: 9509932
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
27
12
2018
revised:
05
02
2019
accepted:
07
02
2019
pubmed:
20
2
2019
medline:
30
4
2019
entrez:
20
2
2019
Statut:
ppublish
Résumé
Serum ferritin reflects total body iron stores, thus a low serum ferritin is used as a parameter of iron deficiency. In healthy adults in Japan, urine ferritin levels were about 5% of serum ferritin levels, with a correlation coefficient of 0.79. It is not known whether a low urine ferritin could serve as a non-invasive screen for iron deficiency. If so, this might be useful for neonates and young children, avoiding phlebotomy to screen for iron deficiency. However, for urinary ferritin screening to be feasible, ferritin must be measurable in the urine and correlate with serum ferritin. Testing should also clarify whether the iron content of ferritin in serum and urine are similar. In this pilot feasibility study we measured ferritin in paired serum and urine samples of healthy adult males, healthy term neonates, growing preterm neonates, and children who had very high serum ferritin levels from liver disorders or iron overload. We detected ferritin in every urine sample, and found a correlation with paired serum ferritin (Spearman correlation coefficient 0.78 of log
Identifiants
pubmed: 30777730
pii: S1079-9796(18)30485-6
doi: 10.1016/j.bcmd.2019.02.001
pmc: PMC6420832
mid: NIHMS1521925
pii:
doi:
Substances chimiques
Ferritins
9007-73-2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
59-62Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK030534
Pays : United States
Organisme : NIDDK NIH HHS
ID : R37 DK030534
Pays : United States
Organisme : NIDDK NIH HHS
ID : U54 DK110858
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.
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