Nicotinamide Phosphoribosyltransferase Acts as a Metabolic Gate for Mobilization of Myeloid-Derived Suppressor Cells.
Animals
Apoptosis
Cell Proliferation
Colorectal Neoplasms
/ genetics
Female
Hematopoiesis
Humans
Mammary Neoplasms, Experimental
/ genetics
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Mice, Nude
Myeloid-Derived Suppressor Cells
/ metabolism
NAD
/ metabolism
Nicotinamide Phosphoribosyltransferase
/ genetics
Sarcoma, Experimental
/ genetics
Signal Transduction
Tumor Cells, Cultured
Xenograft Model Antitumor Assays
Journal
Cancer research
ISSN: 1538-7445
Titre abrégé: Cancer Res
Pays: United States
ID NLM: 2984705R
Informations de publication
Date de publication:
15 04 2019
15 04 2019
Historique:
received:
19
05
2018
revised:
31
12
2018
accepted:
13
02
2019
pubmed:
20
2
2019
medline:
22
1
2020
entrez:
20
2
2019
Statut:
ppublish
Résumé
Cancer induces alteration of hematopoiesis to fuel disease progression. We report that in tumor-bearing mice the macrophage colony-stimulating factor elevates the myeloid cell levels of nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme in the NAD salvage pathway, which acts as negative regulator of the CXCR4 retention axis of hematopoietic cells in the bone marrow. NAMPT inhibits CXCR4 through a NAD/Sirtuin 1-mediated inactivation of HIF1α-driven
Identifiants
pubmed: 30777853
pii: 0008-5472.CAN-18-1544
doi: 10.1158/0008-5472.CAN-18-1544
doi:
Substances chimiques
NAD
0U46U6E8UK
Nicotinamide Phosphoribosyltransferase
EC 2.4.2.12
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1938-1951Informations de copyright
©2019 American Association for Cancer Research.