Heterogeneity of humoral immune response to Leishmania tropica in an experimental model.
Animals
Antibodies, Protozoan
/ blood
Disease Models, Animal
Humans
Immunity, Humoral
/ immunology
Immunoglobulin G
/ blood
Iran
Leishmania major
/ immunology
Leishmania tropica
/ immunology
Leishmaniasis, Cutaneous
/ immunology
Lymph Nodes
Mice
Mice, Inbred BALB C
Parasite Load
Spleen
/ parasitology
Antibody
Iran
Leishmania tropica
Lesion size
Parasite load
Journal
Parasitology research
ISSN: 1432-1955
Titre abrégé: Parasitol Res
Pays: Germany
ID NLM: 8703571
Informations de publication
Date de publication:
Apr 2019
Apr 2019
Historique:
received:
29
09
2018
accepted:
11
02
2019
pubmed:
20
2
2019
medline:
6
5
2019
entrez:
20
2
2019
Statut:
ppublish
Résumé
Humoral (antibody) response is an important part of immunity against pathogens. Despite the clear role of cell-mediated immune response in protection against leishmaniasis, the role of humoral responses is challenging. There is very limited data regarding humoral immune response against Leishmania tropica which is the causative agent of human cutaneous leishmaniasis in many parts of the world. Here, we have compared pathogenicity and antibody response against six Iranian Leishmania tropica isolates in BALB/c mice. A Leishmania major isolate was used for comparison. The parasites were injected into the mice followed by the evaluation of the lesion development, parasite load, and antibody responses (IgG1 and IgG2a). Our findings showed that some isolates caused the large lesions and high parasite load in the spleen and lymph node, while other isolates led to no lesion, no splenic parasitism, and low parasite load in the lymph node. The more pathogenic isolates induced higher antibody responses (IgG1 and IgG2a). Our results indicated that there is substantial heterogeneity among various Leishmania tropica isolates regarding the humoral immune response as well as the pathogenicity.
Identifiants
pubmed: 30778754
doi: 10.1007/s00436-019-06256-3
pii: 10.1007/s00436-019-06256-3
doi:
Substances chimiques
Antibodies, Protozoan
0
Immunoglobulin G
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1231-1237Références
Trans R Soc Trop Med Hyg. 2001 Mar-Apr;95(2):217-24
pubmed: 11355565
Parasitol Int. 2001 Jul;50(2):81-91
pubmed: 11438430
J Immunol. 2001 Dec 15;167(12):6967-74
pubmed: 11739516
Exp Parasitol. 2001 Oct;99(2):97-103
pubmed: 11748963
Nat Rev Immunol. 2002 Nov;2(11):845-58
pubmed: 12415308
J Exp Med. 1964 Aug 1;120:243-51
pubmed: 14206439
J Exp Med. 1964 Aug 1;120:315-28
pubmed: 14206442
J Exp Med. 1964 Aug 1;120:223-42
pubmed: 14208249
Am J Trop Med Hyg. 1992 Dec;47(6):852-92
pubmed: 1471744
Folia Parasitol (Praha). 2003 Dec;50(4):241-50
pubmed: 14971592
Am J Trop Med Hyg. 2004 Apr;70(4):364-72
pubmed: 15100448
J Exp Med. 2005 Mar 7;201(5):747-54
pubmed: 15753208
J Immunol. 2005 May 15;174(10):6340-5
pubmed: 15879134
Int J Parasitol. 2006 Feb;36(2):237-46
pubmed: 16307745
Science. 2005 Dec 2;310(5753):1510-2
pubmed: 16322460
Science. 1992 Jul 24;257(5069):539-42
pubmed: 1636090
J Exp Med. 2006 Jan 23;203(1):177-88
pubmed: 16418399
Vaccine. 2006 Jul 17;24(29-30):5708-17
pubmed: 16740346
Annu Rev Immunol. 1990;8:303-33
pubmed: 1693082
Parasite Immunol. 2007 May;29(5):229-39
pubmed: 17430546
Korean J Parasitol. 2007 Dec;45(4):247-53
pubmed: 18165706
J Immunol. 2010 Dec 1;185(11):6939-46
pubmed: 21037092
World Health Organ Tech Rep Ser. 2010;(949):xii-xiii, 1-186, back cover
pubmed: 21485694
Iran J Parasitol. 2011 Mar;6(1):41-8
pubmed: 22347273
PLoS Negl Trop Dis. 2012;6(6):e1667
pubmed: 22679519
Trop Med Int Health. 2012 Nov;17(11):1335-44
pubmed: 22947226
J Nanobiotechnology. 2014 Apr 26;12:17
pubmed: 24766820
Parasitol Int. 2015 Feb;64(1):70-8
pubmed: 25316605
Curr Protoc Immunol. 2015 Feb 02;108:19.2.1-24
pubmed: 25640990
J Microbiol Immunol Infect. 2017 Apr;50(2):160-166
pubmed: 26066544
Mol Immunol. 2017 Nov;91:202-208
pubmed: 28963929
Parasitol Res. 2018 Sep;117(9):2949-2956
pubmed: 29978420
PLoS One. 2018 Sep 24;13(9):e0204491
pubmed: 30248142
Science. 1987 May 22;236(4804):944-7
pubmed: 3107127
Mem Inst Oswaldo Cruz. 1988 Nov;83 Suppl 1:506-13
pubmed: 3267033
Trans R Soc Trop Med Hyg. 1986;80(1):113-9
pubmed: 3726972
J Exp Med. 1971 Feb 1;133(2):289-304
pubmed: 5133863
Infect Immun. 1979 Nov;26(2):611-4
pubmed: 546790
J Immunol. 1984 Apr;132(4):2072-7
pubmed: 6230400
J Exp Med. 1994 Apr 1;179(4):1367-71
pubmed: 7908325
J Immunol. 1998 Apr 15;160(8):3627-30
pubmed: 9558060
J Exp Med. 1998 Jul 6;188(1):217-22
pubmed: 9653099
Exp Parasitol. 1998 Jul;89(3):331-42
pubmed: 9676711