Investigation of human apoB48 metabolism using a new, integrated non-steady-state model of apoB48 and apoB100 kinetics.
apolipoprotein B48
kinetics
model
remnants
stable isotope
Journal
Journal of internal medicine
ISSN: 1365-2796
Titre abrégé: J Intern Med
Pays: England
ID NLM: 8904841
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
pubmed:
20
2
2019
medline:
8
5
2020
entrez:
20
2
2019
Statut:
ppublish
Résumé
Triglyceride-rich lipoproteins and their remnants have emerged as major risk factors for cardiovascular disease. New experimental approaches are required that permit simultaneous investigation of the dynamics of chylomicrons (CM) and apoB48 metabolism and of apoB100 in very low-density lipoproteins (VLDL). Mass spectrometric techniques were used to determine the masses and tracer enrichments of apoB48 in the CM, VLDL The kinetic model described the metabolism of apoB48 in CM, VLDL This novel non-steady-state model integrates the metabolic properties of both apoB100 and apoB48 and the kinetics of triglyceride. The model is physiologically relevant and provides insight not only into apoB48 release in the basal and postabsorptive states but also into the contribution of the intestine to VLDL pool size and kinetics.
Sections du résumé
BACKGROUND
Triglyceride-rich lipoproteins and their remnants have emerged as major risk factors for cardiovascular disease. New experimental approaches are required that permit simultaneous investigation of the dynamics of chylomicrons (CM) and apoB48 metabolism and of apoB100 in very low-density lipoproteins (VLDL).
METHODS
Mass spectrometric techniques were used to determine the masses and tracer enrichments of apoB48 in the CM, VLDL
RESULTS
The kinetic model described the metabolism of apoB48 in CM, VLDL
DISCUSSION
This novel non-steady-state model integrates the metabolic properties of both apoB100 and apoB48 and the kinetics of triglyceride. The model is physiologically relevant and provides insight not only into apoB48 release in the basal and postabsorptive states but also into the contribution of the intestine to VLDL pool size and kinetics.
Identifiants
pubmed: 30779243
doi: 10.1111/joim.12877
pmc: PMC6849847
doi:
Substances chimiques
Apolipoprotein B-100
0
Apolipoprotein B-48
0
Lipoproteins, VLDL
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
562-577Commentaires et corrections
Type : CommentIn
Type : CommentIn
Informations de copyright
© 2019 The Authors. Journal of Internal Medicine published by John Wiley & Sons Ltd on behalf of Association for Publication of The Journal of Internal Medicine.
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