S-protected gellan gum: Decisive approach towards mucoadhesive antimicrobial vaginal films.
Adhesiveness
Animals
Anti-Bacterial Agents
/ chemistry
Caco-2 Cells
Drug Carriers
/ chemistry
Drug Liberation
Escherichia coli
/ drug effects
Female
Humans
Materials Testing
Metronidazole
/ chemistry
Mucous Membrane
/ chemistry
Polysaccharides, Bacterial
/ chemistry
Rheology
Sulfur
/ chemistry
Swine
Vagina
/ chemistry
Metronidazole
Mucoadhesion
Thiolated polymer
Thiomers
Vaginal drug delivery
Journal
International journal of biological macromolecules
ISSN: 1879-0003
Titre abrégé: Int J Biol Macromol
Pays: Netherlands
ID NLM: 7909578
Informations de publication
Date de publication:
01 Jun 2019
01 Jun 2019
Historique:
received:
04
12
2018
revised:
08
02
2019
accepted:
15
02
2019
pubmed:
20
2
2019
medline:
10
8
2019
entrez:
20
2
2019
Statut:
ppublish
Résumé
The aim of this study was to synthesize novel polymeric excipients forming mucoadhesive films for treatment of vaginal microbial infections. 2-(2-Amino ethyldisulfanyl) nicotinic acid was conjugated with gellan gum via amide bond formation. The structure of the resulting S-protected gellan gum was confirmed by
Identifiants
pubmed: 30779984
pii: S0141-8130(18)36642-X
doi: 10.1016/j.ijbiomac.2019.02.092
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Drug Carriers
0
Polysaccharides, Bacterial
0
Metronidazole
140QMO216E
Sulfur
70FD1KFU70
gellan gum
7593U09I4D
Types de publication
Journal Article
Langues
eng
Pagination
148-157Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.