Modulation of TCR-dependent NFAT signaling is impaired in HIV-1 Nef isolates from elite controllers.

HIV Infections / immunology HIV Long-Term Survivors Host-Pathogen Interactions Humans NFATC Transcription Factors / antagonists & inhibitors Receptors, Antigen, T-Cell / metabolism Signal Transduction nef Gene Products, Human Immunodeficiency Virus / metabolism
HIV-1 controllers NFAT Nef Signal transduction T cell receptor

Journal

Virology
ISSN: 1096-0341
Titre abrégé: Virology
Pays: United States
ID NLM: 0110674

Informations de publication

Date de publication:
04 2019
Historique:
received: 12 12 2018
revised: 09 02 2019
accepted: 10 02 2019
pubmed: 20 2 2019
medline: 23 8 2019
entrez: 20 2 2019
Statut: ppublish

Résumé

HIV-1 Nef modulates the activation state of CD4

Identifiants

DOI: 10.1016/j.virol.2019.02.008 PMID: 30780124
pubmed: 30780124
pii: S0042-6822(19)30049-2
doi: 10.1016/j.virol.2019.02.008
pii:
doi:

Substances chimiques

NFATC Transcription Factors 0
Receptors, Antigen, T-Cell 0
nef Gene Products, Human Immunodeficiency Virus 0
nef protein, Human immunodeficiency virus 1 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Pagination

39-50

Subventions

Organisme : CIHR
ID : THA-118569
Pays : Canada
Organisme : CIHR
ID : HOP-115700
Pays : Canada
Organisme : CIHR
ID : MOP-93536
Pays : Canada

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

Auteurs

Steven W Jin (SW)

Faculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada.

Tristan J Markle (TJ)

Dept. of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada.

Gursev Anmole (G)

Dept. of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada.

Asa Rahimi (A)

Faculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada.

Xiaomei T Kuang (XT)

Dept. of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada.

Zabrina L Brumme (ZL)

Faculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC, Canada.

Mark A Brockman (MA)

Faculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada; Dept. of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC, Canada. Electronic address: mark_brockman@sfu.ca.

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Classifications MeSH

questionsmedicales.fr › Maladies du système immunitaire › Déficits immunitaires › Infections à VIH › Modulation of TCR-dependent NFAT signaling is...
questionsmedicales.fr › Personnes › Survivants › Survivants à long terme d'une infection à VIH › Modulation of TCR-dependent NFAT signaling is...
questionsmedicales.fr › Phénomènes biologiques › Interactions hôte-microbes › Interactions hôte-pathogène › Modulation of TCR-dependent NFAT signaling is...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Modulation of TCR-dependent NFAT signaling is...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription NFATC › Modulation of TCR-dependent NFAT signaling is...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs aux antigènes › Récepteurs aux antigènes des cellules T › Modulation of TCR-dependent NFAT signaling is...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Modulation of TCR-dependent NFAT signaling is...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines virales › Protéines virales régulatrices ou accessoires › Produits du gène nef › Produits du gène nef du virus de l'immunodéficience humaine › Modulation of TCR-dependent NFAT signaling is...