Plasma Concentrations of High Molecular Weight Kininogen and Prekallikrein and Venous Thromboembolism Incidence in the General Population.
Blood Coagulation
Case-Control Studies
Cohort Studies
Female
Follow-Up Studies
Humans
Incidence
Kallikrein-Kinin System
Kininogen, High-Molecular-Weight
/ blood
Male
Middle Aged
Plasma
/ metabolism
Population Groups
Prekallikrein
/ metabolism
Prospective Studies
Risk
United States
/ epidemiology
Venous Thromboembolism
/ epidemiology
Journal
Thrombosis and haemostasis
ISSN: 2567-689X
Titre abrégé: Thromb Haemost
Pays: Germany
ID NLM: 7608063
Informations de publication
Date de publication:
May 2019
May 2019
Historique:
pubmed:
20
2
2019
medline:
10
1
2020
entrez:
20
2
2019
Statut:
ppublish
Résumé
The kallikrein/kinin system, an intravascular biochemical pathway that includes several proteins involved in the contact activation system of coagulation, renin-angiotensin activation and inflammation, may or may not play a role in venous thromboembolism (VTE) occurrence. Within a large prospective population-based study in the United States, we conducted a nested case-cohort study to test the hypothesis that higher plasma levels of high molecular weight kininogen (HK) or prekallikrein are associated with greater VTE incidence. We related baseline enzyme-linked immunosorbent assay measures of HK and prekallikrein in 1993 to 1995 to incidence VTE of the lower extremity (
Identifiants
pubmed: 30780167
doi: 10.1055/s-0039-1678737
pmc: PMC6499653
mid: NIHMS1005758
doi:
Substances chimiques
Kininogen, High-Molecular-Weight
0
Prekallikrein
9055-02-1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
834-843Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL059367
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700002C
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700001I
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700004I
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700004C
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700003I
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700005C
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700001C
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700003C
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700002I
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700005I
Pays : United States
Informations de copyright
Georg Thieme Verlag KG Stuttgart · New York.
Déclaration de conflit d'intérêts
None declared.
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