Potential of Zerumbone as an Anti-Cancer Agent.
Antineoplastic Agents
/ administration & dosage
Apoptosis
/ drug effects
Cell Line, Tumor
Cell Survival
/ drug effects
Humans
Interleukin-6
/ metabolism
Janus Kinase 2
/ metabolism
Molecular Structure
STAT3 Transcription Factor
/ drug effects
Sesquiterpenes
/ administration & dosage
Signal Transduction
Transcription Factor RelA
/ drug effects
Zingiberaceae
/ chemistry
Akt
FOXO1
IL-6/JAK2/STAT3
NF-κB
apoptosis
cancer
zerumbone
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
18 Feb 2019
18 Feb 2019
Historique:
received:
21
12
2018
revised:
15
02
2019
accepted:
16
02
2019
entrez:
21
2
2019
pubmed:
20
2
2019
medline:
3
1
2020
Statut:
epublish
Résumé
Cancer is still a major risk factor to public health globally, causing approximately 9.8 million deaths worldwide in 2018. Despite advances in conventional treatment modalities for cancer treatment, there are still few effective therapies available due to the lack of selectivity, adverse side effects, non-specific toxicities, and tumour recurrence. Therefore, there is an immediate need for essential alternative therapeutics, which can prove to be beneficial and safe against cancer. Various phytochemicals from natural sources have been found to exhibit beneficial medicinal properties against various human diseases. Zerumbone is one such compound isolated from
Identifiants
pubmed: 30781671
pii: molecules24040734
doi: 10.3390/molecules24040734
pmc: PMC6413012
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Interleukin-6
0
RELA protein, human
0
STAT3 Transcription Factor
0
Sesquiterpenes
0
Transcription Factor RelA
0
zerumbone
471-05-6
JAK2 protein, human
EC 2.7.10.2
Janus Kinase 2
EC 2.7.10.2
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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