Increased TGF-β and BMP Levels and Improved Chondrocyte-Specific Marker Expression In Vitro under Cartilage-Specific Physiological Osmolarity.

Biomarkers / metabolism Bone Morphogenetic Proteins / metabolism Cartilage, Articular / metabolism Chondrocytes / metabolism Collagen Type II / genetics Gene Expression Regulation Humans Organ Specificity Osmolar Concentration Protein Isoforms / metabolism RNA Interference Transforming Growth Factor beta / metabolism
TGF-β superfamily bone morphogenetic proteins chondrocyte collagen type II osmolarity signalling

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
13 Feb 2019
Historique:
received: 30 12 2018
revised: 31 01 2019
accepted: 07 02 2019
entrez: 21 2 2019
pubmed: 20 2 2019
medline: 5 6 2019
Statut: epublish

Résumé

During standard expansion culture (i.e., plasma osmolarity, 280 mOsm) human articular chondrocytes dedifferentiate, making them inappropriate for autologous chondrocyte implantation to treat cartilage defects. Increasing the osmolarity of culture media to physiological osmolarity levels of cartilage (i.e., 380 mOsm), increases collagen type II (

Identifiants

DOI: 10.3390/ijms20040795 PMID: 30781744 PMC: PMC6412363
pubmed: 30781744
pii: ijms20040795
doi: 10.3390/ijms20040795
pmc: PMC6412363
pii:
doi:

Substances chimiques

Biomarkers 0
Bone Morphogenetic Proteins 0
Collagen Type II 0
Protein Isoforms 0
Transforming Growth Factor beta 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Seventh Framework Programme
ID : 305815
Organisme : Reumafonds
ID : LLP14

Références

Clin Orthop Relat Res. 1999 Oct;(367 Suppl):S147-55
pubmed: 10546643
Stroke. 2000 Sep;31(9):2043-8
pubmed: 10978027
Nat Rev Mol Cell Biol. 2000 Dec;1(3):169-78
pubmed: 11252892
J Biol Chem. 2002 Feb 15;277(7):4883-91
pubmed: 11729207
Osteoarthritis Cartilage. 2002 Aug;10(8):631-7
pubmed: 12479385
Genes Cells. 2002 Dec;7(12):1191-204
pubmed: 12485160
Cell. 2003 Jun 13;113(6):685-700
pubmed: 12809600
J Biol Chem. 1992 Sep 25;267(27):19027-30
pubmed: 1326540
Cell Tissue Bank. 2000;1(4):255-60
pubmed: 15256934
Osteoarthritis Cartilage. 2005 Aug;13(8):697-708
pubmed: 15950496
Arthritis Res Ther. 2005;7(6):R1338-47
pubmed: 16277687
Mol Reprod Dev. 1992 Jun;32(2):91-8
pubmed: 1637557
Am J Pathol. 2006 Jan;168(1):131-40
pubmed: 16400016
J Bone Miner Res. 2008 Jun;23(6):896-906
pubmed: 18333754
Cell Res. 2009 Jan;19(1):71-88
pubmed: 19002158
Clin Chem. 2009 Apr;55(4):611-22
pubmed: 19246619
J Immunol. 2009 Jun 15;182(12):7937-45
pubmed: 19494318
Osteoarthritis Cartilage. 2009 Dec;17(12):1539-45
pubmed: 19583961
Tissue Eng Part A. 2010 Jan;16(1):1-10
pubmed: 19604038
Am J Physiol Cell Physiol. 2009 Oct;297(4):C898-906
pubmed: 19657054
J Orthop Res. 2010 Apr;28(4):537-45
pubmed: 19813243
Int Orthop. 2010 Jun;34(5):621-30
pubmed: 20162416
Arthritis Res Ther. 2010;12(3):R100
pubmed: 20492652
Osteoarthritis Cartilage. 2010 Nov;18(11):1518-27
pubmed: 20833252
Nucleic Acids Res. 2011 Jan;39(Database issue):D52-7
pubmed: 21115458
Osteoarthritis Cartilage. 2011 Aug;19(8):1036-46
pubmed: 21640843
J Biol Chem. 2012 Jan 20;287(4):2446-58
pubmed: 22147700
Arthritis Rheum. 2012 Jun;64(6):1929-39
pubmed: 22231955
Osteoarthritis Cartilage. 2012 Oct;20(10):1170-8
pubmed: 22796508
Bone. 2013 Mar;53(1):94-102
pubmed: 23219947
Cell Tissue Res. 2014 Jan;355(1):163-71
pubmed: 24192939
Proc Natl Acad Sci U S A. 1986 Jun;83(12):4167-71
pubmed: 2424019
Matrix Biol. 2014 Nov;40:10-6
pubmed: 25172826
Int J Mol Sci. 2014 Dec 12;15(12):23090-140
pubmed: 25514413
Ann Anat. 2015 Mar;198:1-10
pubmed: 25621374
Arthritis Rheumatol. 2015 Nov;67(11):2944-56
pubmed: 26245691
Br Med Bull. 2015;116:93-103
pubmed: 26491082
Zhejiang Da Xue Xue Bao Yi Xue Ban. 2016 Mar;45(2):179-86
pubmed: 27273992
Trends Biochem Sci. 2016 Nov;41(11):970-981
pubmed: 27669651
Nat Rev Rheumatol. 2017 Mar;13(3):155-163
pubmed: 28148919
Tissue Eng Part A. 2018 Feb;24(3-4):264-274
pubmed: 28474537
Osteoarthritis Cartilage. 2017 Nov;25(11):1868-1879
pubmed: 28716756
Cartilage. 2019 Apr;10(2):186-195
pubmed: 28992763
Cartilage. 2018 Jul;9(3):313-320
pubmed: 29156946
Int J Mol Sci. 2018 May 18;19(5):null
pubmed: 29783650
Cell. 1978 Dec;15(4):1313-21
pubmed: 729001
J Cell Physiol. 1993 Feb;154(2):262-70
pubmed: 8425907
Development. 1997 Jul;124(13):2659-70
pubmed: 9217007
Nature. 1997 Dec 4;390(6659):465-71
pubmed: 9393997
EMBO J. 1998 Jun 1;17(11):3091-100
pubmed: 9606191

Auteurs

Ufuk Tan Timur (U)

Laboratory for Experimental Orthopedics, Department of Orthopaedic Surgery, Maastricht University Medical Centre+, 6229 HX Maastricht, The Netherlands. u.timur@maastrichtuniversity.nl.
Institute of Anatomy and Cell Biology, RWTH Aachen University, 52074 Aachen, Germany.. u.timur@maastrichtuniversity.nl.

Marjolein Caron (M)

Laboratory for Experimental Orthopedics, Department of Orthopaedic Surgery, Maastricht University Medical Centre+, 6229 HX Maastricht, The Netherlands. marjolein.caron@maastrichtuniversity.nl.

Guus van den Akker (G)

Laboratory for Experimental Orthopedics, Department of Orthopaedic Surgery, Maastricht University Medical Centre+, 6229 HX Maastricht, The Netherlands. g.vandenakker@maastrichtuniversity.nl.

Anna van der Windt (A)

Department of Orthopaedics, Erasmus MC, University Medical Center, 3000 CA Rotterdam, The Netherlands. a.vanderwindt@erasmusmc.nl.
ORCID: 0000-0002-6244-7946

Jenny Visser (J)

Department of Internal Medicine, Erasmus MC, University Medical Center, 3000 CA Rotterdam, The Netherlands. j.visser@erasmusmc.nl.
ORCID: 0000-0001-7182-3571

Lodewijk van Rhijn (L)

Laboratory for Experimental Orthopedics, Department of Orthopaedic Surgery, Maastricht University Medical Centre+, 6229 HX Maastricht, The Netherlands. L.van.rhijn@mumc.nl.

Harrie Weinans (H)

Department of Orthopaedics, University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands. h.h.weinans@umcutrecht.nl.
Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands. h.h.weinans@umcutrecht.nl.
Department of Biomechanical Engineering, Delft University of Technology, 2628 CD Delft, The Netherlands. h.h.weinans@umcutrecht.nl.

Tim Welting (T)

Laboratory for Experimental Orthopedics, Department of Orthopaedic Surgery, Maastricht University Medical Centre+, 6229 HX Maastricht, The Netherlands. t.welting@maastrichtuniversity.nl.

Pieter Emans (P)

Laboratory for Experimental Orthopedics, Department of Orthopaedic Surgery, Maastricht University Medical Centre+, 6229 HX Maastricht, The Netherlands. p.emans@mumc.nl.

Holger Jahr (H)

Laboratory for Experimental Orthopedics, Department of Orthopaedic Surgery, Maastricht University Medical Centre+, 6229 HX Maastricht, The Netherlands. hjahr@ukaachen.de.
Institute of Anatomy and Cell Biology, RWTH Aachen University, 52074 Aachen, Germany.. hjahr@ukaachen.de.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Increased TGF-β and BMP Levels and Improved...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Protéines de la superfamille du TGF bêta › Protéines morphogénétiques osseuses › Increased TGF-β and BMP Levels and Improved...
questionsmedicales.fr › Appareil locomoteur › Squelette › Articulations › Cartilage articulaire › Increased TGF-β and BMP Levels and Improved...
questionsmedicales.fr › Cellules › Cellules du tissu conjonctif › Chondrocytes › Increased TGF-β and BMP Levels and Improved...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Scléroprotéines › Protéines de la matrice extracellulaire › Collagène › Collagènes fibrillaires › Collagène de type II › Increased TGF-β and BMP Levels and Improved...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Increased TGF-β and BMP Levels and Improved...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Increased TGF-β and BMP Levels and Improved...
questionsmedicales.fr › Phénomènes physiologiques › Spécificité d'organe › Increased TGF-β and BMP Levels and Improved...
questionsmedicales.fr › Phénomènes chimiques › Concentration osmolaire › Increased TGF-β and BMP Levels and Improved...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Isoformes de protéines › Increased TGF-β and BMP Levels and Improved...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Extinction de l'expression des gènes › Interférence par ARN › Increased TGF-β and BMP Levels and Improved...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Protéines de la superfamille du TGF bêta › Facteur de croissance transformant bêta › Increased TGF-β and BMP Levels and Improved...