Folic Acid and Vitamin B12 Administration in CKD, Why Not?
cardiovascular disease
chronic kidney disease
end-stage renal disease
folic acid
hyperhomocysteinemia
vitamin B12
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
13 Feb 2019
13 Feb 2019
Historique:
received:
29
01
2019
revised:
09
02
2019
accepted:
11
02
2019
entrez:
21
2
2019
pubmed:
20
2
2019
medline:
25
4
2019
Statut:
epublish
Résumé
Patients affected by chronic kidney disease (CKD) or end-stage renal disease (ESRD) experience a huge cardiovascular risk and cardiovascular events represent the leading causes of death. Since traditional risk factors cannot fully explain such increased cardiovascular risk, interest in non-traditional risk factors, such as hyperhomocysteinemia and folic acid and vitamin B12 metabolism impairment, is growing. Although elevated homocysteine blood levels are often seen in patients with CKD and ESRD, whether hyperhomocysteinemia represents a reliable cardiovascular and mortality risk marker or a therapeutic target in this population is still unclear. In addition, folic acid and vitamin B12 could not only be mere cofactors in the homocysteine metabolism; they may have a direct action in determining tissue damage and cardiovascular risk. The purpose of this review was to highlight homocysteine, folic acid and vitamin B12 metabolism impairment in CKD and ESRD and to summarize available evidences on hyperhomocysteinemia, folic acid and vitamin B12 as cardiovascular risk markers, therapeutic target and risk factors for CKD progression.
Identifiants
pubmed: 30781775
pii: nu11020383
doi: 10.3390/nu11020383
pmc: PMC6413093
pii:
doi:
Substances chimiques
Biomarkers
0
Homocysteine
0LVT1QZ0BA
Folic Acid
935E97BOY8
Vitamin B 12
P6YC3EG204
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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