Hypoxia Pathway Proteins in Normal and Malignant Hematopoiesis.
HIF
hematopoietic stem cells
hypoxia
leukemia
oxygen sensors
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
13 02 2019
13 02 2019
Historique:
received:
18
01
2019
revised:
06
02
2019
accepted:
08
02
2019
entrez:
21
2
2019
pubmed:
20
2
2019
medline:
20
2
2019
Statut:
epublish
Résumé
The regulation of oxygen (O₂) levels is crucial in embryogenesis and adult life, as O₂ controls a multitude of key cellular functions. Low oxygen levels (hypoxia) are relevant for tissue physiology as they are integral to adequate metabolism regulation and cell fate. Hence, the hypoxia response is of utmost importance for cell, organ and organism function and is dependent on the hypoxia-inducible factor (HIF) pathway. HIF pathway activity is strictly regulated by the family of oxygen-sensitive HIF prolyl hydroxylase domain (PHD) proteins. Physiologic hypoxia is a hallmark of the hematopoietic stem cell (HSC) niche in the bone marrow. This niche facilitates HSC quiescence and survival. The present review focuses on current knowledge and the many open questions regarding the impact of PHDs/HIFs and other proteins of the hypoxia pathway on the HSC niche and on normal and malignant hematopoiesis.
Identifiants
pubmed: 30781787
pii: cells8020155
doi: 10.3390/cells8020155
pmc: PMC6406588
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
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