Glycosylation of HIV Env Impacts IgG Subtype Responses to Vaccination.
AIDS Vaccines
/ immunology
Animals
Glycosylation
HIV Antibodies
/ immunology
Hemagglutinin Glycoproteins, Influenza Virus
/ genetics
Immunity, Humoral
Immunoglobulin G
/ immunology
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Mice, Knockout
Th2 Cells
/ immunology
Vaccines, DNA
/ immunology
Viral Fusion Proteins
/ genetics
env Gene Products, Human Immunodeficiency Virus
/ immunology
HIV env
antibody response
glycosylation
vaccination
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
13 02 2019
13 02 2019
Historique:
received:
22
01
2019
revised:
06
02
2019
accepted:
10
02
2019
entrez:
21
2
2019
pubmed:
20
2
2019
medline:
21
8
2019
Statut:
epublish
Résumé
The envelope protein (Env) is the only surface protein of the human immunodeficiency virus (HIV) and as such the exclusive target for protective antibody responses. Experimental evidences from mouse models suggest a modulating property of Env to steer antibody class switching towards the less effective antibody subclass IgG1 accompanied with strong TH2 helper responses. By simple physical linkage we were able to imprint this bias, exemplified by a low IgG2a/IgG1 ratio of antigen-specific antibodies, onto an unrelated antigen, namely the HIV capsid protein p24. Here, our results indicate the glycan moiety of Env as the responsible immune modulating activity. Firstly, in
Identifiants
pubmed: 30781796
pii: v11020153
doi: 10.3390/v11020153
pmc: PMC6410111
pii:
doi:
Substances chimiques
AIDS Vaccines
0
F protein, human respiratory syncytial virus
0
HIV Antibodies
0
Hemagglutinin Glycoproteins, Influenza Virus
0
Immunoglobulin G
0
Vaccines, DNA
0
Viral Fusion Proteins
0
env Gene Products, Human Immunodeficiency Virus
0
hemagglutinin, human influenza A virus
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
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