The Enigmatic Protein Kinase C-eta.
PKCη
apoptosis
cell proliferation
differentiation
drug resistance
protein kinase C
senescence
tumor promotion
tumor suppression
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
13 Feb 2019
13 Feb 2019
Historique:
received:
17
01
2019
revised:
04
02
2019
accepted:
10
02
2019
entrez:
21
2
2019
pubmed:
20
2
2019
medline:
20
2
2019
Statut:
epublish
Résumé
Protein kinase C (PKC), a multi-gene family, plays critical roles in signal transduction and cell regulation. Protein kinase C-eta (PKCη) is a unique member of the PKC family since its regulation is distinct from other PKC isozymes. PKCη was shown to regulate cell proliferation, differentiation and cell death. It was also shown to contribute to chemoresistance in several cancers. PKCη has been associated with several cancers, including renal cell carcinoma, glioblastoma, breast cancer, non-small cell lung cancer, and acute myeloid leukemia. However, mice lacking PKCη were more susceptible to tumor formation in a two-stage carcinogenesis model, and it is downregulated in hepatocellular carcinoma. Thus, the role of PKCη in cancer remains controversial. The purpose of this review article is to discuss how PKCη regulates various cellular processes that may contribute to its contrasting roles in cancer.
Identifiants
pubmed: 30781807
pii: cancers11020214
doi: 10.3390/cancers11020214
pmc: PMC6406448
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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