In Vitro Susceptibility to Metronidazole of Tritrichomonas foetus Bovine Isolates from Argentina.
Bovine trichomonosis
In vitro susceptibility
Metronidazole
Tritrichomonas foetus isolates
Journal
Acta parasitologica
ISSN: 1896-1851
Titre abrégé: Acta Parasitol
Pays: Switzerland
ID NLM: 9301947
Informations de publication
Date de publication:
Jun 2019
Jun 2019
Historique:
received:
22
08
2018
accepted:
03
02
2019
pubmed:
21
2
2019
medline:
18
12
2019
entrez:
21
2
2019
Statut:
ppublish
Résumé
Tritrichomonas foetus is the etiologic agent of the sexually transmitted disease Bovine Trichomonosis (BT). In Argentina, BT is endemic and represents a relevant health problem that causes reproductive inefficiency in cattle and large economic losses. Metronidazole is the drug of choice in the treatment of BT. Treatment has been associated with a temporary resolution of the clinical signs but is not able to control the disease. In recent years, the apparition of in vivo and in vitro aerobic and anaerobic resistance leading to ineffective treatments has been reported. Thus, the aim of the present study was to explore the susceptibility of six different isolates of T. foetus under aerobic (AC) and anaerobic (ANC) conditions. Six isolates of T. foetus were obtained from samples of preputial smegma of bovine origin. Values of minimum lethal concentration and minimum inhibitory concentration were higher than those observed in other works and represent current data in Argentina and provide information to establish new treatment protocols.
Sections du résumé
BACKGROUND
BACKGROUND
Tritrichomonas foetus is the etiologic agent of the sexually transmitted disease Bovine Trichomonosis (BT). In Argentina, BT is endemic and represents a relevant health problem that causes reproductive inefficiency in cattle and large economic losses. Metronidazole is the drug of choice in the treatment of BT. Treatment has been associated with a temporary resolution of the clinical signs but is not able to control the disease. In recent years, the apparition of in vivo and in vitro aerobic and anaerobic resistance leading to ineffective treatments has been reported.
AIMS
OBJECTIVE
Thus, the aim of the present study was to explore the susceptibility of six different isolates of T. foetus under aerobic (AC) and anaerobic (ANC) conditions.
RESULTS AND DISCUSSION
CONCLUSIONS
Six isolates of T. foetus were obtained from samples of preputial smegma of bovine origin. Values of minimum lethal concentration and minimum inhibitory concentration were higher than those observed in other works and represent current data in Argentina and provide information to establish new treatment protocols.
Identifiants
pubmed: 30783992
doi: 10.2478/s11686-019-00031-1
pii: 10.2478/s11686-019-00031-1
doi:
Substances chimiques
Antiprotozoal Agents
0
Metronidazole
140QMO216E
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM