Fungal Translocation Is Associated with Immune Activation and Systemic Inflammation in Treated HIV.
Adult
Antibodies, Fungal
/ blood
Antiviral Agents
/ therapeutic use
Biomarkers
/ blood
Cohort Studies
Cross-Sectional Studies
Female
Glucans
/ blood
HIV Infections
/ blood
Humans
Immunoglobulin A
/ blood
Immunoglobulin G
/ blood
Inflammation
Lymphocyte Activation
Male
Middle Aged
Saccharomyces cerevisiae
/ immunology
HIV
biomarkers
fungi
gastrointestinal microbiome
inflammation
Journal
AIDS research and human retroviruses
ISSN: 1931-8405
Titre abrégé: AIDS Res Hum Retroviruses
Pays: United States
ID NLM: 8709376
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
pubmed:
21
2
2019
medline:
17
4
2020
entrez:
21
2
2019
Statut:
ppublish
Résumé
The mechanisms causing HIV-associated immune activation remain incompletely understood. Alteration of intestinal integrity with subsequent translocation of bacterial products appears to play an important role; however, little is known about the impact of fungal translocation. We assessed the effect of fungal translocation and its association with immune activation in people living with HIV (PLWH) compared with uninfected controls. We measured serum levels of β-D-glucan (BDG) and anti-
Identifiants
pubmed: 30784316
doi: 10.1089/AID.2018.0252
pmc: PMC6516070
doi:
Substances chimiques
Antibodies, Fungal
0
Antiviral Agents
0
Biomarkers
0
Glucans
0
Immunoglobulin A
0
Immunoglobulin G
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
461-472Subventions
Organisme : NHLBI NIH HHS
ID : R56 HL126526
Pays : United States
Organisme : NHLBI NIH HHS
ID : R56 HL126539
Pays : United States
Organisme : NHLBI NIH HHS
ID : R00 HL108743
Pays : United States
Organisme : NIDDK NIH HHS
ID : R21 DK118757
Pays : United States
Organisme : NICHD NIH HHS
ID : K23 HD088295
Pays : United States
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