Trans ε viniferin decreases amyloid deposits and inflammation in a mouse transgenic Alzheimer model.
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2019
2019
Historique:
received:
07
05
2018
accepted:
08
02
2019
entrez:
21
2
2019
pubmed:
21
2
2019
medline:
26
11
2019
Statut:
epublish
Résumé
As Alzheimer's disease (AD) induces several cellular and molecular damages, it could be interesting to use multi-target molecules for therapeutics. We previously published that trans ε-viniferin induced the disaggregation of Aβ42 peptide and inhibited the inflammatory response in primary cellular model of AD. Here, effects of this stilbenoid were evaluated in transgenic APPswePS1dE9 mice. We report that trans ε-viniferin could go through the blood brain barrier, reduces size and density of amyloid deposits and decreases reactivity of astrocytes and microglia, after a weekly intraperitoneal injection at 10 mg/kg from 3 to 6 months of age.
Identifiants
pubmed: 30785960
doi: 10.1371/journal.pone.0212663
pii: PONE-D-18-13651
pmc: PMC6382128
doi:
Substances chimiques
Benzofurans
0
Stilbenes
0
epsilon-viniferin
62218-08-0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0212663Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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