RIPK3-Induced Inflammation by I-MDSCs Promotes Intestinal Tumors.

Animals Colorectal Neoplasms / metabolism Granulocyte-Macrophage Colony-Stimulating Factor / metabolism Humans Inflammation / metabolism Interleukins / metabolism Mice Mice, Inbred C57BL Myeloid-Derived Suppressor Cells / metabolism Receptor-Interacting Protein Serine-Threonine Kinases / antagonists & inhibitors

Journal

Cancer research
ISSN: 1538-7445
Titre abrégé: Cancer Res
Pays: United States
ID NLM: 2984705R

Informations de publication

Date de publication:
01 04 2019
Historique:
received: 12 07 2018
revised: 05 01 2019
accepted: 13 02 2019
pubmed: 23 2 2019
medline: 1 1 2020
entrez: 22 2 2019
Statut: ppublish

Résumé

Myeloid-derived suppressor cells (MDSC) promote colorectal cancer by several mechanisms, including suppression of antitumor T cells and production of tumorigenic factors. We previously showed that an intermediate MDSC subset (I-MDSC) is expanded in an intestinal tumor model (Apc

Identifiants

DOI: 10.1158/0008-5472.CAN-18-2153 PMID: 30786994 PMC: PMC7395226
pubmed: 30786994
pii: 0008-5472.CAN-18-2153
doi: 10.1158/0008-5472.CAN-18-2153
pmc: PMC7395226
mid: NIHMS1607750
doi:

Substances chimiques

Interleukins 0
Granulocyte-Macrophage Colony-Stimulating Factor 83869-56-1
RIPK3 protein, human EC 2.7.11.1
Receptor-Interacting Protein Serine-Threonine Kinases EC 2.7.11.1

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

1587-1599

Subventions

Organisme : NCI NIH HHS
ID : R01 CA168670
Pays : United States

Informations de copyright

©2019 American Association for Cancer Research.

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Auteurs

Asha Jayakumar (A)

Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut.

Alfred L M Bothwell (ALM)

Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut. alfred.bothwell@yale.edu.
ORCID: 0000-0003-2477-2104

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › RIPK3-Induced Inflammation by I-MDSCs Promotes...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Maladies du rectum › Tumeurs colorectales › RIPK3-Induced Inflammation by I-MDSCs Promotes...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Facteurs de croissance hématopoïétique › Facteurs de stimulation des colonies › Facteur de stimulation des colonies de granulocytes et de macrophages › RIPK3-Induced Inflammation by I-MDSCs Promotes...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › RIPK3-Induced Inflammation by I-MDSCs Promotes...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › RIPK3-Induced Inflammation by I-MDSCs Promotes...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interleukines › RIPK3-Induced Inflammation by I-MDSCs Promotes...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › RIPK3-Induced Inflammation by I-MDSCs Promotes...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › RIPK3-Induced Inflammation by I-MDSCs Promotes...
questionsmedicales.fr › Cellules › Cellules myéloïdes › Cellules myéloïdes suppressives › RIPK3-Induced Inflammation by I-MDSCs Promotes...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Receptor-Interacting Protein Serine-Threonine Kinases › RIPK3-Induced Inflammation by I-MDSCs Promotes...