Impaired insulin sensitivity is associated with worsening cognition in HIV-infected patients.
Journal
Neurology
ISSN: 1526-632X
Titre abrégé: Neurology
Pays: United States
ID NLM: 0401060
Informations de publication
Date de publication:
19 03 2019
19 03 2019
Historique:
received:
10
10
2017
accepted:
08
11
2018
pubmed:
23
2
2019
medline:
18
12
2019
entrez:
22
2
2019
Statut:
ppublish
Résumé
To determine the association of insulin sensitivity and metabolic status with declining cognition in HIV-infected individuals. We conducted targeted clinical and metabolic measures in longitudinal plasma samples obtained from HIV-infected patients enrolled in the Central Nervous System HIV Anti-Retroviral Therapy Effects Research Study (CHARTER). Findings were validated with plasma samples from the Multicenter AIDS Cohort Study (MACS). Patients were grouped according to longitudinally and serially assessed cognitive performance as having stably normal or declining cognition. Patients with declining cognition exhibited baseline hyperinsulinemia and elevated plasma c-peptide levels with normal c-peptide/insulin ratios, suggesting that insulin production was increased, but insulin clearance was normal. The association of hyperinsulinemia with worsening cognition was further supported by low high-density lipoprotein (HDL), high low-density lipoprotein/HDL ratio, and elevated cholesterol/HDL ratio compared to patients with stably normal cognition. These findings suggest that hyperinsulinemia and impaired insulin sensitivity are associated with cognitive decline in antiretroviral therapy-treated HIV-infected patients.
Identifiants
pubmed: 30787163
pii: WNL.0000000000007125
doi: 10.1212/WNL.0000000000007125
pmc: PMC6511093
doi:
Substances chimiques
Anti-HIV Agents
0
C-Peptide
0
Lipoproteins
0
Types de publication
Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1344-e1353Subventions
Organisme : NIAID NIH HHS
ID : U01 AI035042
Pays : United States
Organisme : NIMH NIH HHS
ID : P30 MH075673
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI035041
Pays : United States
Organisme : NIAID NIH HHS
ID : UM1 AI035043
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH077542
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL146201
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH110246
Pays : United States
Organisme : NIMH NIH HHS
ID : P30 MH062512
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI035039
Pays : United States
Organisme : NIMH NIH HHS
ID : P01 MH105280
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001079
Pays : United States
Organisme : NIA NIH HHS
ID : R21 AG034849
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH107345
Pays : United States
Organisme : NIMH NIH HHS
ID : R25 MH080661
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI035040
Pays : United States
Informations de copyright
© 2019 American Academy of Neurology.
Références
Neurology. 2012 Feb 14;78(7):485-92
pubmed: 22330412
Nat Rev Immunol. 2005 Jan;5(1):69-81
pubmed: 15630430
AIDS Res Hum Retroviruses. 2012 May;28(5):447-53
pubmed: 21878059
J Neurovirol. 2016 Dec;22(6):823-830
pubmed: 27273074
Neurology. 2010 Nov 30;75(22):1982-7
pubmed: 21115952
Ethiop Med J. 2012 Jul;50(3):221-30
pubmed: 23409405
Arch Neurol. 2005 Jul;62(7):1067-72
pubmed: 16009759
Neurology. 2010 Dec 7;75(23):2087-96
pubmed: 21135382
J Neuroimmune Pharmacol. 2013 Dec;8(5):1123-35
pubmed: 24101401
Diabetologia. 1985 Jul;28(7):412-9
pubmed: 3899825
Clin Infect Dis. 2002 Jan 15;34(2):248-59
pubmed: 11740715
J Clin Exp Neuropsychol. 2004 May;26(3):307-19
pubmed: 15512922
Ann N Y Acad Sci. 1996 Jan 17;777:374-9
pubmed: 8624116
Endocrinology. 1979 Sep;105(3):666-73
pubmed: 223829
Can J Infect Dis Med Microbiol. 2005 Jul;16(4):230-2
pubmed: 18159550
Neurology. 1993 Nov;43(11):2245-52
pubmed: 8232937
Neuron. 2012 Sep 6;75(5):762-77
pubmed: 22958818
Eur J Clin Invest. 1994 Jun;24(6):416-20
pubmed: 7957495
Clin Infect Dis. 2008 Apr 15;46(8):1290-6
pubmed: 18444869
Neurobiol Learn Mem. 2011 Oct;96(3):432-42
pubmed: 21907815
J Acquir Immune Defic Syndr. 2015 Mar 1;68(3):281-8
pubmed: 25469522
AIDS. 2015 Mar 13;29(5):559-69
pubmed: 25611149
J Alzheimers Dis. 2005 Feb;7(1):63-80
pubmed: 15750215
Diabet Med. 2003 Apr;20(4):255-68
pubmed: 12675638
J Neurosci Res. 2003 Jul 1;73(1):1-9
pubmed: 12815703
FASEB J. 2008 Jan;22(1):246-60
pubmed: 17720802
J Clin Invest. 2012 Apr;122(4):1316-38
pubmed: 22476197
J Neurosci. 2012 Jun 27;32(26):8940-51
pubmed: 22745494
J Neurovirol. 2009 Jul;15(4):324-33
pubmed: 19499454
Acta Neuropathol. 1994;87(4):343-8
pubmed: 8017169
Am J Physiol. 1990 Sep;259(3 Pt 1):E378-83
pubmed: 2205107
Science. 1997 Jan 31;275(5300):661-5
pubmed: 9005851
J Clin Exp Neuropsychol. 2011 Jun;33(5):505-22
pubmed: 21391011
J Stroke Cerebrovasc Dis. 2008 Jul-Aug;17(4):212-7
pubmed: 18589342
J Biol Chem. 1999 Dec 3;274(49):34893-902
pubmed: 10574963
J Neuroinflammation. 2010 Feb 14;7:13
pubmed: 20152054
Physiol Behav. 2007 Nov 23;92(4):691-701
pubmed: 17585961
J Clin Invest. 1993 Oct;92(4):1824-30
pubmed: 8408635
Lancet. 1998 Mar 21;351(9106):871-5
pubmed: 9525365
J Nucl Med. 1991 Sep;32(9):1725-9
pubmed: 1880574
J Clin Endocrinol Metab. 1992 May;74(5):1045-52
pubmed: 1373735
Peptides. 1997;18(8):1257-62
pubmed: 9396070
J Neurochem. 2005 Jun;93(6):1568-78
pubmed: 15935073
J Acquir Immune Defic Syndr. 2006 Dec 1;43(4):458-66
pubmed: 16980905
Int J Epidemiol. 2015 Oct;44(5):1506-16
pubmed: 24771276
PLoS Pathog. 2011 Sep;7(9):e1002213
pubmed: 21909266
Neurochem Int. 1993 Jan;22(1):1-10
pubmed: 8443563