Protein kinase/phosphatase balance mediates the effects of increased late sodium current on ventricular calcium cycling.

Action Potentials / physiology Animals Calcium / metabolism Calcium-Calmodulin-Dependent Protein Kinase Type 2 / metabolism Mice Myocytes, Cardiac / metabolism Protein Phosphatase 1 / metabolism Protein Phosphatase 2 / metabolism Sodium / metabolism
CaMKII Calcium cycling Late sodium current PKA PP1 PP2A SR calcium leak

Journal

Basic research in cardiology
ISSN: 1435-1803
Titre abrégé: Basic Res Cardiol
Pays: Germany
ID NLM: 0360342

Informations de publication

Date de publication:
20 02 2019
Historique:
received: 04 05 2018
accepted: 12 02 2019
entrez: 22 2 2019
pubmed: 23 2 2019
medline: 14 6 2019
Statut: epublish

Résumé

Increased late sodium current (late I

Identifiants

DOI: 10.1007/s00395-019-0720-7 PMID: 30788598
pubmed: 30788598
doi: 10.1007/s00395-019-0720-7
pii: 10.1007/s00395-019-0720-7
doi:

Substances chimiques

Sodium 9NEZ333N27
Calcium-Calmodulin-Dependent Protein Kinase Type 2 EC 2.7.11.17
Protein Phosphatase 1 EC 3.1.3.16
Protein Phosphatase 2 EC 3.1.3.16
Calcium SY7Q814VUP

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

13

Subventions

Organisme : European Research Council
ID : 336567
Pays : International

Auteurs

Jörg Eiringhaus (J)

Abt. Kardiologie und Pneumologie/Herzzentrum, Georg-August-Universität Göttingen, Robert-Koch-Str. 40, 37075, Göttingen, Germany.
Abt. Kardiologie und Angiologie, Medizinische Hochschule Hannover, Hannover, Germany.
Deutsches Zentrum für Herz-Kreislauf Forschung (DZHK), Standort Göttingen, Göttingen, Germany.

Jonas Herting (J)

Abt. Kardiologie und Pneumologie/Herzzentrum, Georg-August-Universität Göttingen, Robert-Koch-Str. 40, 37075, Göttingen, Germany.
Deutsches Zentrum für Herz-Kreislauf Forschung (DZHK), Standort Göttingen, Göttingen, Germany.

Felix Schatter (F)

Abt. Kardiologie und Pneumologie/Herzzentrum, Georg-August-Universität Göttingen, Robert-Koch-Str. 40, 37075, Göttingen, Germany.
Deutsches Zentrum für Herz-Kreislauf Forschung (DZHK), Standort Göttingen, Göttingen, Germany.

Viacheslav O Nikolaev (VO)

Institut für Experimentelle Herz-Kreislaufforschung, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany.

Julia Sprenger (J)

Abt. Kardiologie und Pneumologie/Herzzentrum, Georg-August-Universität Göttingen, Robert-Koch-Str. 40, 37075, Göttingen, Germany.

Yansong Wang (Y)

European Molecular Biology Laboratory, Genome Biology Unit, Heidelberg, Germany.

Maja Köhn (M)

European Molecular Biology Laboratory, Genome Biology Unit, Heidelberg, Germany.
Centre for Biological Signalling Studies (BIOSS) and Faculty of Biology, University of Freiburg, Freiburg, Germany.

Markus Zabel (M)

Abt. Kardiologie und Pneumologie/Herzzentrum, Georg-August-Universität Göttingen, Robert-Koch-Str. 40, 37075, Göttingen, Germany.
Deutsches Zentrum für Herz-Kreislauf Forschung (DZHK), Standort Göttingen, Göttingen, Germany.

Ali El-Armouche (A)

Institut für Pharmakologie und Toxikologie, Technische Universität Dresden, Dresden, Germany.

Gerd Hasenfuss (G)

Abt. Kardiologie und Pneumologie/Herzzentrum, Georg-August-Universität Göttingen, Robert-Koch-Str. 40, 37075, Göttingen, Germany.
Deutsches Zentrum für Herz-Kreislauf Forschung (DZHK), Standort Göttingen, Göttingen, Germany.

Samuel Sossalla (S)

Abt. Kardiologie und Pneumologie/Herzzentrum, Georg-August-Universität Göttingen, Robert-Koch-Str. 40, 37075, Göttingen, Germany.
Klinik und Poliklinik für Innere Medizin II, Universitätsklinikum Regensburg, Regensburg, Germany.
Deutsches Zentrum für Herz-Kreislauf Forschung (DZHK), Standort Göttingen, Göttingen, Germany.

Thomas H Fischer (TH)

Abt. Kardiologie und Pneumologie/Herzzentrum, Georg-August-Universität Göttingen, Robert-Koch-Str. 40, 37075, Göttingen, Germany. thomas.fischer@med.uni-goettingen.de.
Medizinische Klinik II, Kardiologie, Angiologie, Pneumologie, Klinikum Coburg, Coburg, Germany. thomas.fischer@med.uni-goettingen.de.
Deutsches Zentrum für Herz-Kreislauf Forschung (DZHK), Standort Göttingen, Göttingen, Germany. thomas.fischer@med.uni-goettingen.de.
ORCID: 0000-0002-7324-2575

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Potentiels de membrane › Potentiels d'action › Protein kinase/phosphatase balance mediates...
questionsmedicales.fr › Eucaryotes › Animaux › Protein kinase/phosphatase balance mediates...
questionsmedicales.fr › Facteurs biologiques › Facteurs de la coagulation sanguine › Calcium › Protein kinase/phosphatase balance mediates...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Calcium-Calmodulin-Dependent Protein Kinases › Calcium-Calmodulin-Dependent Protein Kinase Type 2 › Protein kinase/phosphatase balance mediates...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Protein kinase/phosphatase balance mediates...
questionsmedicales.fr › Cellules › Cellules musculaires › Myocytes cardiaques › Protein kinase/phosphatase balance mediates...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Phosphoprotein Phosphatases › Protein Phosphatase 1 › Protein kinase/phosphatase balance mediates...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Phosphoprotein Phosphatases › Protein Phosphatase 2 › Protein kinase/phosphatase balance mediates...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux légers › Sodium › Protein kinase/phosphatase balance mediates...