Aqueous extracts of Syzygium brazzavillense can inhibit the infection with coxsackievirus B4 in vitro.
Republic of Congo
antiviral activity
aqueous extracts
enterovirus
plant
Journal
Journal of medical virology
ISSN: 1096-9071
Titre abrégé: J Med Virol
Pays: United States
ID NLM: 7705876
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
21
12
2018
revised:
07
02
2019
accepted:
12
02
2019
pubmed:
23
2
2019
medline:
10
4
2020
entrez:
22
2
2019
Statut:
ppublish
Résumé
Traditional practitioners commonly use plant crude extracts to treat various diseases in patients with symptoms that can be seen during enterovirus infections. In this study, the antienteroviral activity of medicinal plants from the Republic of Congo has been evaluated in vitro. Through an ethnopharmacological approach, seven plants grouped into six families were identified. Aqueous and organic extracts of various organs from these plants were prepared. The organic extracts at subcytotoxic concentrations did not inhibit the cytopathic effect (CPE) induced by coxsackievirus (CV)B1-5, CVA6, poliovirus type 1, and enterovirus 71. The aqueous extract of Syzygium brazzavillense, but not those of other plants, inhibited the CPE induced by CVB3 and CVB4 at 30 µg/mL (CC
Substances chimiques
Antiviral Agents
0
Plant Extracts
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1210-1216Informations de copyright
© 2019 Wiley Periodicals, Inc.