Outcomes after salvage radical prostatectomy and first-line radiation therapy or HIFU for recurrent localized prostate cancer: results from a multicenter study.
Prostate neoplasm
Radical prostatectomy
Recurrence: radiation therapy
Salvage
Survival
Journal
World journal of urology
ISSN: 1433-8726
Titre abrégé: World J Urol
Pays: Germany
ID NLM: 8307716
Informations de publication
Date de publication:
Aug 2019
Aug 2019
Historique:
received:
31
07
2018
accepted:
14
02
2019
pubmed:
23
2
2019
medline:
20
2
2020
entrez:
22
2
2019
Statut:
ppublish
Résumé
Despite no consensus on the optimal management of recurrent prostate cancer after primary radiation or HIFU therapy, salvage prostatectomy (sRP) is reserved for only 3% of patients because of technical challenges and frequent post-operative complications. We assessed outcomes after sRP in a series of patients with localized PCa and that had received radiation therapy or HIFU as a first-line treatment. Data from nine French referral centers on patients treated with sRP between 2005 and 2017 were collected. Pre- and post-operative data, including oncological and functional outcomes after first treatment and sRP, were analyzed to determine the predictors for biochemical recurrence (BCR) and cancer-specific survival (CSS) after sRP. First-line treatments were external beam-radiation therapy (EBRT) for 30 (55%), brachytherapy (BT) for 10 (18%), and high-intensity focused ultrasound (HIFU) for 15 (27%). Median (IQR) PSA at diagnosis was 6.4 (4.9-9.5) ng/mL, median PSA at nadir was 1.9 (0.7-3.0) ng/mL, and median (IQR) to first BCR was 13 (6-20) months. Of the 55 patients, 44 (80%) received robot-assisted salvage radical prostatectomy and 11 (20%) received salvage retropubic radical prostatectomy. Restoration of continence was achieved in 90% of preoperatively continent patients; 24% that had received nerve-sparing (NS) procedures were potent after surgery. Prolonged catheterization due to anastomotic leakage was the most common complication. Age, preoperative clinical stage, NS procedure, and a pathological Gleason score were predictors for BCR. sRP was safe, feasible, and effective using either an open or robot-assisted approach, in experienced hands. Age, preoperative clinical stage, NS procedure, and pathological GS were linked with BCR after sRP.
Identifiants
pubmed: 30790014
doi: 10.1007/s00345-019-02683-0
pii: 10.1007/s00345-019-02683-0
doi:
Types de publication
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
1491-1498Références
Rozet F, Hennequin C, Beauval J-B, Beuzeboc P, Cormier L, Fromont G et al (2016) Recommandations en onco-urologie 2016–2018 du CCAFU: cancer de la prostate. Prog En Urol 27:S95–S143
doi: 10.1016/S1166-7087(16)30705-9
Siegel RL, Miller KD, Jemal A (2018) Cancer statistics, 2018. CA Cancer J Clin 68(1):7–30
doi: 10.3322/caac.21442
Cooperberg MR, Modak S, Konety BR (2007) Trends in Regionalization of inpatient care for urological malignancies, 1988–2002. J Urol 178:2103–2108
doi: 10.1016/j.juro.2007.07.040
Mottet N, Bellmunt J, Bolla M, Briers E, Cumberbatch MG, De Santis M et al (2016) EAU-ESTRO-SIOG guidelines on prostate cancer. Part 1: screening, diagnosis, and local treatment with curative intent. Eur Urol 71:1–12
Roach M, Hanks G, Thames H, Schellhammer P, Shipley WU, Sokol GH et al (2006) Defining biochemical failure following radiotherapy with or without hormonal therapy in men with clinically localized prostate cancer: recommendations of the RTOG-ASTRO Phoenix Consensus Conference. Int J Radiat Oncol Biol Phys 65(4):965–974
doi: 10.1016/j.ijrobp.2006.04.029
Bates AS, Samavedi S, Kumar A, Mouraviev V, Rocco B, Coelho R et al (2015) Salvage robot assisted radical prostatectomy: a propensity matched study of perioperative, oncological and functional outcomes. Eur J Surg Oncol 41(11):1540–1546
doi: 10.1016/j.ejso.2015.06.002
Rocco B, Cozzi G, Spinelli MG, Grasso A, Varisco D, Coelho RF et al (2012) Current status of salvage robot-assisted laparoscopic prostatectomy for radiorecurrent prostate cancer. Curr Urol Rep 13(3):195–201
doi: 10.1007/s11934-012-0245-1
Abdul-Muhsin H, Samavedi S, Pereira C, Palmer K, Patel V (2013) Salvage robot-assisted radical prostatectomy. BJU Int 111(4):686–687
doi: 10.1111/bju.12073
Ogaya-Pinies G, Linares-Espinos E, Hernandez-Cardona E, Jenson C, Cathelineau X, Sanchez-Salas R et al (2018) Salvage robotic-assisted radical prostatectomy: oncologic and functional outcomes from two high-volume institutions. World J Urol. https://doi.org/10.1007/s00345-018-2406-4
doi: 10.1007/s00345-018-2406-4
pubmed: 30006908
Gotto GT, Yunis LH, Vora K, Eastham JA, Scardino PT, Rabbani F (2010) Impact of prior prostate radiation on complications after radical prostatectomy. J Urol 184(1):136–142
doi: 10.1016/j.juro.2010.03.031
Stephenson AJ, Scardino PT, Bianco FJ, Diblasio CJ, Fearn PA, Eastham JA (2004) Morbidity and functional outcomes of salvage radical prostatectomy for locally recurrent prostate cancer after radiation therapy. J Urol 172(6):2239–2243
doi: 10.1097/01.ju.0000140960.63108.39
Darras J, Joniau S, Van Poppel H (2006) Salvage radical prostatectomy for radiorecurrent prostate cancer: indications and results. Eur J Surg Oncol EJSO 32(9):964–969
doi: 10.1016/j.ejso.2006.05.015
Gill I, Cacciamani G (2018) LBA3 the changing face of urologic oncologic surgery from 2000–2018 (63,141 patients)—impact of robotics. J Urol 199(4):e577–e578
Klayton TL, Ruth K, Buyyounouski MK, Uzzo RG, Wong Y-N, Chen DYT et al (2011) Prostate-specific antigen doubling time predicts the development of distant metastases for patients who fail 3-dimensional conformal radiotherapy or intensity modulated radiation therapy using the Phoenix definition. Pract Radiat Oncol 1(4):235–242
doi: 10.1016/j.prro.2011.02.003
Dindo D, Demartines N, Clavien P-A (2004) Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg 240(2):205–213
doi: 10.1097/01.sla.0000133083.54934.ae
Mador DR, Huben RP, Wajsman Z, Pontes JE (1985) Salvage surgery following radical radiotherapy for adenocarcinoma of the prostate. J Urol 133(1):58–60
doi: 10.1016/S0022-5347(17)48780-5
Kenney PA, Nawaf CB, Mustafa M, Wen S, Wszolek MF, Pettaway CA et al (2016) Robotic-assisted laparoscopic versus open salvage radical prostatectomy following radiotherapy. Can J Urol 23(3):8271–8277
pubmed: 27347619
pmcid: 5512888
Yuh B, Ruel N, Muldrew S, Mejia R, Novara G, Kawachi M et al (2014) Complications and outcomes of salvage robot-assisted radical prostatectomy: a single-institution experience. BJU Int 113(5):769–776
doi: 10.1111/bju.12595
Kaffenberger SD, Keegan KA, Bansal NK, Morgan TM, Tang DH, Barocas DA et al (2013) Salvage robotic assisted laparoscopic radical prostatectomy: a single institution, 5-year experience. J Urol 189(2):507–513
doi: 10.1016/j.juro.2012.09.057
Zugor V, Labanaris AP, Porres D, Heidenreich A, Witt JH (2014) Robot-assisted radical prostatectomy for the treatment of radiation-resistant prostate cancer: surgical, oncological and short-term functional outcomes. Urol Int 92(1):20–26
doi: 10.1159/000351948
Eandi JA, Link BA, Nelson RA, Josephson DY, Lau C, Kawachi MH et al (2010) Robotic assisted laparoscopic salvage prostatectomy for radiation resistant prostate cancer. J Urol 183(1):133–137
doi: 10.1016/j.juro.2009.08.134
Matei DV, Ferro M, Jereczek-Fossa BA, Renne G, Crisan N, Bottero D et al (2015) Salvage radical prostatectomy after external beam radiation therapy: a systematic review of current approaches. Urol Int 94(4):373–382
doi: 10.1159/000371893
Mandel P, Steuber T, Ahyai S, Kriegmair M, Schiffmann J, Boehm K et al (2016) Salvage radical prostatectomy for recurrent prostate cancer: verification of European Association of Urology guideline criteria. BJU Int 117(1):55–61
doi: 10.1111/bju.13103
Kaouk JH, Hafron J, Goel R, Haber G-P, Jones JS (2008) Robotic salvage retropubic prostatectomy after radiation/brachytherapy: initial results. BJU Ints 102(1):93–96
doi: 10.1111/j.1464-410X.2008.07570.x