Strengthening the AntiTumor NK Cell Function for the Treatment of Ovarian Cancer.
B7-H6
NK cells
PD-1
activating receptors
adoptive therapy
antitumor activity
hormone therapy
immune checkpoint
immunotherapy
ovarian cancer
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
19 Feb 2019
19 Feb 2019
Historique:
received:
31
01
2019
revised:
13
02
2019
accepted:
15
02
2019
entrez:
23
2
2019
pubmed:
23
2
2019
medline:
5
6
2019
Statut:
epublish
Résumé
The crosstalk between cancer cells and host cells is a crucial prerequisite for tumor growth and progression. The cells from both the innate and adaptive immune systems enter into a perverse relationship with tumor cells to create a tumor-promoting and immunosuppressive tumor microenvironment (TME). Epithelial ovarian cancer (EOC), the most lethal of all gynecological malignancies, is characterized by a unique TME that paves the way to the formation of metastasis and mediates therapy resistance through the deregulation of immune surveillance. A characteristic feature of the ovarian cancer TME is the ascites/peritoneal fluid, a malignancy-associated effusion occurring at more advanced stages, which enables the peritoneal dissemination of tumor cells and the formation of metastasis. The standard therapy for EOC involves a combination of debulking surgery and platinum-based chemotherapy. However, most patients experience disease recurrence. New therapeutic strategies are needed to improve the prognosis of patients with advanced EOC. Harnessing the body's natural immune defenses against cancer in the form of immunotherapy is emerging as an innovative treatment strategy. NK cells have attracted attention as a promising cancer immunotherapeutic target due to their ability to kill malignant cells and avoid healthy cells. Here, we will discuss the recent advances in the clinical application of NK cell immunotherapy in EOC.
Identifiants
pubmed: 30791364
pii: ijms20040890
doi: 10.3390/ijms20040890
pmc: PMC6412350
pii:
doi:
Substances chimiques
Biomarkers, Tumor
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Associazione Italiana per la Ricerca sul Cancro
ID : 21147
Organisme : Associazione Italiana per la Ricerca sul Cancro
ID : 20312
Organisme : Associazione Italiana per la Ricerca sul Cancro
ID : 21534
Organisme : Roche
ID : -
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