DNA Methylation in Inflammatory Pathways Modifies the Association between BMI and Adult-Onset Non-Atopic Asthma.
DNA methylation
adult-onset asthma
epigenetics
epigenome-wide association study
inflammation
innate immunity
non-atopic asthma
obesity
Journal
International journal of environmental research and public health
ISSN: 1660-4601
Titre abrégé: Int J Environ Res Public Health
Pays: Switzerland
ID NLM: 101238455
Informations de publication
Date de publication:
19 02 2019
19 02 2019
Historique:
received:
20
11
2018
revised:
14
02
2019
accepted:
15
02
2019
entrez:
23
2
2019
pubmed:
23
2
2019
medline:
25
6
2019
Statut:
epublish
Résumé
A high body mass (BMI) index has repeatedly been associated with non-atopic asthma, but the biological mechanism linking obesity to asthma is still poorly understood. We aimed to test the hypothesis that inflammation and/or innate immunity plays a role in the obesity-asthma link. DNA methylome was measured in blood samples of 61 non-atopic participants with asthma and 146 non-atopic participants without asthma (non-smokers for at least 10 years) taking part in the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA) study. Modification by DNA methylation of the association of BMI or BMI change over 10 years with adult-onset asthma was examined at each CpG site and differentially methylated region. Pathway enrichment tests were conducted for genes in a priori curated inflammatory pathways and the NLRP3-IL1B-IL17 axis. The latter was chosen on the basis of previous work in mice. Inflammatory pathways including glucocorticoid/PPAR signaling (
Identifiants
pubmed: 30791383
pii: ijerph16040600
doi: 10.3390/ijerph16040600
pmc: PMC6406386
pii:
doi:
Substances chimiques
NF-kappa B
0
PPAR gamma
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Medical Research Council
ID : MR/L01341X/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 084703MA
Pays : United Kingdom
Références
BMC Bioinformatics. 2012 May 08;13:86
pubmed: 22568884
Am J Respir Crit Care Med. 2010 Feb 15;181(4):315-23
pubmed: 19892860
J Allergy Clin Immunol. 2008 May;121(5):1087-93; quiz 1094-5
pubmed: 18405959
Am J Respir Crit Care Med. 2008 Aug 1;178(3):218-224
pubmed: 18480428
J Gerontol A Biol Sci Med Sci. 2017 Apr 1;72(4):513-519
pubmed: 27567109
Sci Rep. 2013;3:2164
pubmed: 23857381
PLoS Med. 2014 Jul 01;11(7):e1001669
pubmed: 24983943
Stat Appl Genet Mol Biol. 2015 Jun;14(3):279-93
pubmed: 26030794
Soz Praventivmed. 2005;50(4):245-63
pubmed: 16167509
PLoS One. 2007 Oct 17;2(10):e1035
pubmed: 17940599
Lancet. 2014 Jun 7;383(9933):1990-8
pubmed: 24630777
J Clin Invest. 2003 Dec;112(12):1796-808
pubmed: 14679176
Endocrinol Metab (Seoul). 2017 Dec;32(4):442-450
pubmed: 29199402
Bioinformatics. 2013 Jan 15;29(2):189-96
pubmed: 23175756
Bioinformatics. 2014 May 15;30(10):1363-9
pubmed: 24478339
J Allergy Clin Immunol. 2015 Mar;135(3):626-35
pubmed: 25528359
J Allergy Clin Immunol. 2019 Jun;143(6):2062-2074
pubmed: 30579849
Nat Protoc. 2009;4(1):44-57
pubmed: 19131956
Stat Appl Genet Mol Biol. 2005;4:Article29
pubmed: 16646847
Front Immunol. 2016 Jan 05;6:637
pubmed: 26779183
Epigenetics Chromatin. 2015 Jan 27;8:6
pubmed: 25972926
Nat Genet. 2009 Feb;41(2):178-186
pubmed: 19151715
Eur Respir J. 2009 May;33(5):1003-9
pubmed: 19196817
Diabetologia. 2013 Nov;56(11):2487-97
pubmed: 24013717
Thorax. 2014 Aug;69(8):752-9
pubmed: 24736287
Arterioscler Thromb Vasc Biol. 2005 Oct;25(10):2062-8
pubmed: 16123319
Nature. 2017 Jan 5;541(7635):81-86
pubmed: 28002404
Soz Praventivmed. 1997;42(2):67-84
pubmed: 9151378
Epigenetics. 2014 Sep;9(9):1302-16
pubmed: 25147914
Am J Respir Crit Care Med. 2007 Apr 1;175(7):661-6
pubmed: 17234901
Lancet Respir Med. 2019 Apr;7(4):336-346
pubmed: 30584054
Nucl Receptor Res. 2018;5:
pubmed: 29450204
Nucleic Acids Res. 2013 Apr;41(7):e90
pubmed: 23476028
Nat Med. 2011 Feb;17(2):179-88
pubmed: 21217695
BMC Bioinformatics. 2015 Jul 10;16:217
pubmed: 26156501
Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50
pubmed: 16199517
Genome Biol. 2015 Feb 15;16:37
pubmed: 25853392
Allergy. 2018 Jan;73(1):153-164
pubmed: 28675761
Eur Respir J. 2014 Nov;44(5):1319-31
pubmed: 24925921
Epigenetics. 2013 May;8(5):522-33
pubmed: 23644594
Environ Health Perspect. 2013 Apr;121(4):480-7
pubmed: 23384616
BMC Pediatr. 2013 Aug 13;13:121
pubmed: 23941287
Nat Med. 2014 Jan;20(1):54-61
pubmed: 24336249
Respir Med. 2017 Apr;125:25-32
pubmed: 28340859
Nat Genet. 2011 Jun 26;43(8):768-75
pubmed: 21706001
Am J Clin Nutr. 2005 Oct;82(4):872-8; quiz 915-6
pubmed: 16210719
Mol Cell Endocrinol. 2010 Mar 25;316(2):129-39
pubmed: 19723556
Epigenetics. 2013 Feb;8(2):203-9
pubmed: 23314698
Clin Exp Allergy. 2012 Aug;42(8):1237-45
pubmed: 22805471
Lancet Respir Med. 2018 May;6(5):379-388
pubmed: 29496485