Physiological and Transcriptional Responses in Weaned Piglets Fed Diets with Varying Phosphorus and Calcium Levels.
calcium homeostasis
dietary mineral intake
immunomodulation
phosphorus homeostasis
trabecular bone
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
20 Feb 2019
20 Feb 2019
Historique:
received:
23
01
2019
revised:
14
02
2019
accepted:
18
02
2019
entrez:
23
2
2019
pubmed:
23
2
2019
medline:
2
5
2019
Statut:
epublish
Résumé
Phosphorus (P) is an important element of various metabolic and signalling processes, including bone metabolism and immune function. To elucidate the routes of P homeostasis and utilization, a five-week feeding study was conducted with weaned piglets receiving a diet with recommended amounts of P and Ca (M), or a diet with lower (L) or higher (H) P values and a constant Ca:P ratio. Routes of P utilization were deduced via bone characteristics (MicroCT), genome-wide transcriptomic profiles of peripheral blood mononuclear cells (PBMCs), and serum mineral levels. MicroCT revealed significantly lower bone mineral density, trabecular number, and mechanical fracture load in (L). Gene expression analyses showed transcripts of 276 and 115 annotated genes with higher or lower abundance in (H) than (L) that were related to basic cellular and metabolic processes as well as response to stimuli, developmental processes and immune system processes. This study shows the many molecular routes involved in P homeostasis that should be considered to improve endogenous mechanisms of P utilization.
Identifiants
pubmed: 30791512
pii: nu11020436
doi: 10.3390/nu11020436
pmc: PMC6412343
pii:
doi:
Substances chimiques
Calcium, Dietary
0
Phosphorus, Dietary
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Leibniz Science Campus Phosphorus Research
ID : no Grant Number
Références
Int J Biochem Cell Biol. 1999 Jan;31(1):25-9
pubmed: 10216940
J Bone Miner Res. 2000 Apr;15(4):683-90
pubmed: 10780860
J Nutr. 2000 May;130(5S Suppl):1378S-83S
pubmed: 10801947
Science. 2000 Sep 1;289(5484):1504-8
pubmed: 10968780
Comput Methods Biomech Biomed Engin. 1997;1(1):15-23
pubmed: 11264794
Bone. 2001 Jun;28(6):650-4
pubmed: 11425654
J Anim Sci. 2001 Aug;79(8):2134-42
pubmed: 11518222
Nat Immunol. 2001 Oct;2(10):907-16
pubmed: 11577346
Nucleic Acids Res. 2002 Jan 1;30(1):207-10
pubmed: 11752295
J Anim Physiol Anim Nutr (Berl). 2002 Feb;86(1-2):1-16
pubmed: 11906568
Mol Endocrinol. 2003 Jul;17(7):1255-67
pubmed: 12730332
Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9440-5
pubmed: 12883005
Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):13952-7
pubmed: 14617770
J Nutr Biochem. 2006 Jun;17(6):385-95
pubmed: 16311027
J Interferon Cytokine Res. 2005 Dec;25(12):749-56
pubmed: 16375603
J Lab Clin Med. 2006 Mar;147(3):126-32
pubmed: 16503242
Clin Exp Immunol. 2007 Jan;147(1):164-75
pubmed: 17177976
Semin Immunol. 2007 Apr;19(2):106-15
pubmed: 17324587
Nat Rev Immunol. 2007 Apr;7(4):292-304
pubmed: 17380158
Endocr Rev. 2008 Jun;29(4):403-40
pubmed: 18451259
Bioinformatics. 2009 Feb 1;25(3):415-6
pubmed: 19106121
J Cell Biochem. 2009 Feb 1;106(2):232-46
pubmed: 19115254
Physiology (Bethesda). 2009 Feb;24:17-25
pubmed: 19196648
Proc Natl Acad Sci U S A. 2010 May 25;107(21):9546-51
pubmed: 20460310
J Cell Biochem. 2011 Sep;112(9):2594-605
pubmed: 21598302
Pediatr Nephrol. 2012 Nov;27(11):2039-2048
pubmed: 22552885
J Leukoc Biol. 2013 Feb;93(2):209-15
pubmed: 23108097
BMC Biol. 2012 Nov 15;10:90
pubmed: 23153189
Meat Sci. 2013 Sep;95(1):129-36
pubmed: 23688799
Reumatol Clin. 2013 Sep-Oct;9(5):303-15
pubmed: 23727459
Mol Nutr Food Res. 2014 Feb;58(2):343-52
pubmed: 23963738
Am J Transplant. 2013 Oct;13(10):2530-9
pubmed: 24033923
Biochim Biophys Acta. 2014 May;1843(5):965-75
pubmed: 24487064
Nature. 2014 Jun 5;510(7503):58-67
pubmed: 24899305
Cell Metab. 2015 Mar 3;21(3):502.e1
pubmed: 25738464
Nutr Res Rev. 2015 Jun;28(1):67-82
pubmed: 26004147
BMC Immunol. 2015 Aug 26;16:48
pubmed: 26307036
Nucleic Acids Res. 2016 Jan 4;44(D1):D471-80
pubmed: 26527732
Am J Physiol Regul Integr Comp Physiol. 2016 May 15;310(10):R917-25
pubmed: 26962023
Curr Protoc Bioinformatics. 2016 Jun 20;54:1.30.1-1.30.33
pubmed: 27322403
J Anim Sci. 2016 Aug;94(8):3321-3334
pubmed: 27695786
Nutrients. 2017 Oct 28;9(11):null
pubmed: 29143791
Ambio. 2018 Jan;47(Suppl 1):20-29
pubmed: 29159450
BMC Genomics. 2018 Mar 20;19(1):207
pubmed: 29554878
Horm Metab Res. 1985 Feb;17(2):78-81
pubmed: 3838732
J Anim Sci. 1983 Jul;57(1):43-54
pubmed: 6885664
Cell. 1995 Jun 30;81(7):1159-70
pubmed: 7600583
Eur J Biochem. 1996 Mar 15;236(3):747-71
pubmed: 8665893
Am J Clin Nutr. 1997 Jun;65(6):1803-9
pubmed: 9174476
Exp Physiol. 1998 Sep;83(5):659-65
pubmed: 9793786
J Nutr. 1999 Jan;129(1):188-93
pubmed: 9915898