Characterisation of an Isogenic Model of Cisplatin Resistance in Oesophageal Adenocarcinoma Cells.
cisplatin
inflammation
metabolism
oesophageal cancer
radiation
treatment resistance
Journal
Pharmaceuticals (Basel, Switzerland)
ISSN: 1424-8247
Titre abrégé: Pharmaceuticals (Basel)
Pays: Switzerland
ID NLM: 101238453
Informations de publication
Date de publication:
20 Feb 2019
20 Feb 2019
Historique:
received:
19
12
2018
revised:
14
02
2019
accepted:
15
02
2019
entrez:
23
2
2019
pubmed:
23
2
2019
medline:
23
2
2019
Statut:
epublish
Résumé
Cisplatin (cis-diamminedichloroplatinum) is widely used for the treatment of solid malignancies; however, the development of chemoresistance hinders the success of this chemotherapeutic in the clinic. This study provides novel insights into the molecular and phenotypic changes in an isogenic oesophageal adenocarcinoma (OAC) model of acquired cisplatin resistance. Key differences that could be targeted to overcome cisplatin resistance are highlighted. We characterise the differences in treatment sensitivity, gene expression, inflammatory protein secretions, and metabolic rate in an isogenic cell culture model of acquired cisplatin resistance in OAC. Cisplatin-resistant cells (OE33 Cis R) were significantly more sensitive to other cytotoxic modalities, such as 2 Gy radiation (
Identifiants
pubmed: 30791601
pii: ph12010033
doi: 10.3390/ph12010033
pmc: PMC6469161
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Irish Cancer Society
ID : CRS15BUC
Références
N Engl J Med. 1999 Apr 15;340(15):1154-61
pubmed: 10202166
Br J Cancer. 1999 Jun;80(7):954-63
pubmed: 10362102
Int J Radiat Biol. 2002 May;78(5):417-24
pubmed: 12020431
Oncology (Williston Park). 2002 May;16(5 Suppl 5):11-5
pubmed: 12109799
J Clin Oncol. 2003 Jan 1;21(1):92-8
pubmed: 12506176
Eur J Immunol. 1992 Sep;22(9):2255-60
pubmed: 1355429
Mol Cancer Res. 2005 May;3(5):277-85
pubmed: 15886299
J Immunol. 1991 May 15;146(10):3682-6
pubmed: 1673988
N Engl J Med. 2006 Jul 6;355(1):11-20
pubmed: 16822992
Cell Death Differ. 2007 Aug;14(8):1497-507
pubmed: 17464323
Stem Cell Rev. 2007 Jan;3(1):30-8
pubmed: 17873379
IUBMB Life. 2007 Nov;59(11):696-9
pubmed: 17885832
Curr Genomics. 2007 Apr;8(2):113-28
pubmed: 18660845
World J Gastroenterol. 2009 Dec 21;15(47):5983-91
pubmed: 20014464
Oncogene. 2010 Aug 26;29(34):4741-51
pubmed: 20531305
Radiat Res. 2010 Dec;174(6):703-11
pubmed: 21128793
J Gastrointest Surg. 2011 Mar;15(3):429-38
pubmed: 21246413
Cell. 2011 Mar 4;144(5):646-74
pubmed: 21376230
Oncogene. 2012 Apr 12;31(15):1869-83
pubmed: 21892204
Ann Surg. 2011 Nov;254(5):809-16; discussion 816-7
pubmed: 22005152
Mol Cancer Ther. 2012 Mar;11(3):604-15
pubmed: 22248473
Cancer Biol Ther. 2012 May;13(7):496-503
pubmed: 22415136
N Engl J Med. 2012 May 31;366(22):2074-84
pubmed: 22646630
Pharmacol Rev. 2012 Jul;64(3):706-21
pubmed: 22659329
Dig Surg. 2012;29(3):251-60
pubmed: 22868386
Radiat Oncol. 2013 Mar 27;8:75
pubmed: 23531325
PLoS One. 2014 Jun 26;9(6):e100738
pubmed: 24968221
Int J Cancer. 2015 Mar 1;136(5):E359-86
pubmed: 25220842
Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):14710-5
pubmed: 25267626
Metallomics. 2014 Nov;6(11):2126-33
pubmed: 25306996
Gut. 2015 Mar;64(3):381-7
pubmed: 25320104
World J Gastroenterol. 2014 Oct 28;20(40):14904-12
pubmed: 25356050
J Gastrointest Surg. 2015 May;19(5):964-72
pubmed: 25650163
Cell. 2015 Feb 26;160(5):963-976
pubmed: 25723170
Cancer Lett. 2015 Aug 10;364(2):142-55
pubmed: 25960282
Front Mol Biosci. 2014 Nov 17;1:24
pubmed: 25988165
Sci Rep. 2015 Jul 23;5:12291
pubmed: 26201611
Oncotarget. 2015 Oct 6;6(30):30102-14
pubmed: 26337086
PLoS One. 2015 Nov 16;10(11):e0142834
pubmed: 26571024
World J Clin Oncol. 2016 Feb 10;7(1):106-13
pubmed: 26862494
Nat Immunol. 2016 Jul 19;17(8):906-13
pubmed: 27434011
Oncotarget. 2016 Sep 20;7(38):61890-61904
pubmed: 27542265
Oncotarget. 2017 Feb 14;8(7):11400-11413
pubmed: 28002789
World J Gastroenterol. 2017 Feb 21;23(7):1189-1202
pubmed: 28275299
Ann Cardiothorac Surg. 2017 Mar;6(2):131-136
pubmed: 28447001
BMC Cancer. 2017 Jun 3;17(1):401
pubmed: 28578652
Cell Metab. 2017 Jul 5;26(1):49-70
pubmed: 28683294
J Thorac Dis. 2017 Jul;9(Suppl 8):S697-S704
pubmed: 28815065
Oncogenesis. 2018 May 22;7(5):40
pubmed: 29795279
Oncol Lett. 2018 Jul;16(1):801-808
pubmed: 29971135
Int J Oncol. 2018 Sep;53(3):1055-1068
pubmed: 30015875
Oncotarget. 2018 Sep 14;9(72):33634-33647
pubmed: 30263091
Mol Pharmacol. 1995 Jun;47(6):1255-60
pubmed: 7603468
Genes Dev. 1995 Mar 15;9(6):650-62
pubmed: 7729684
N Engl J Med. 1996 Aug 15;335(7):462-7
pubmed: 8672151