Sleep oscillation-specific associations with Alzheimer's disease CSF biomarkers: novel roles for sleep spindles and tau.
Journal
Molecular neurodegeneration
ISSN: 1750-1326
Titre abrégé: Mol Neurodegener
Pays: England
ID NLM: 101266600
Informations de publication
Date de publication:
21 02 2019
21 02 2019
Historique:
received:
11
09
2018
accepted:
08
02
2019
entrez:
23
2
2019
pubmed:
23
2
2019
medline:
6
7
2019
Statut:
epublish
Résumé
Based on associations between sleep spindles, cognition, and sleep-dependent memory processing, here we evaluated potential relationships between levels of CSF Aβ One-night in-lab nocturnal polysomnography (NPSG) and morning to early afternoon CSF collection were performed to measure CSF Aβ Spindle density during NREM stage 2 (N2) sleep was negatively correlated with CSF Aβ Reduced spindles during N2 sleep may represent an early dysfunction related to tau, possibly reflecting axonal damage or altered neuronal tau secretion, rendering it a potentially novel biomarker for early neuronal dysfunction. Given their putative role in memory consolidation and neuroplasticity, sleep spindles may represent a mechanism by which tau impairs memory consolidation, as well as a possible target for therapeutic interventions in cognitive decline.
Sections du résumé
BACKGROUND
Based on associations between sleep spindles, cognition, and sleep-dependent memory processing, here we evaluated potential relationships between levels of CSF Aβ
METHODS
One-night in-lab nocturnal polysomnography (NPSG) and morning to early afternoon CSF collection were performed to measure CSF Aβ
RESULTS
Spindle density during NREM stage 2 (N2) sleep was negatively correlated with CSF Aβ
CONCLUSIONS
Reduced spindles during N2 sleep may represent an early dysfunction related to tau, possibly reflecting axonal damage or altered neuronal tau secretion, rendering it a potentially novel biomarker for early neuronal dysfunction. Given their putative role in memory consolidation and neuroplasticity, sleep spindles may represent a mechanism by which tau impairs memory consolidation, as well as a possible target for therapeutic interventions in cognitive decline.
Identifiants
pubmed: 30791922
doi: 10.1186/s13024-019-0309-5
pii: 10.1186/s13024-019-0309-5
pmc: PMC6385427
doi:
Substances chimiques
Amyloid beta-Peptides
0
Biomarkers
0
Peptide Fragments
0
amyloid beta-protein (1-42)
0
tau Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
10Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL118624
Pays : United States
Organisme : NIA NIH HHS
ID : R21 AG059179
Pays : United States
Organisme : NHLBI NIH HHS
ID : K24 HL109156
Pays : United States
Organisme : NIA NIH HHS
ID : R21 AG049348
Pays : United States
Organisme : NIA NIH HHS
ID : R21 AG055002
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG022374
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG056682
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG056531
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG056031
Pays : United States
Organisme : NIA NIH HHS
ID : K07 AG052685
Pays : United States
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