Epidermal loss of phospholipase Cδ1 attenuates irritant contact dermatitis.
DTECs
Gr1(+)CD11b(+) myeloid cells
ICD
Keratinocytes
PLC
Journal
Biochemical and biophysical research communications
ISSN: 1090-2104
Titre abrégé: Biochem Biophys Res Commun
Pays: United States
ID NLM: 0372516
Informations de publication
Date de publication:
02 04 2019
02 04 2019
Historique:
received:
04
02
2019
accepted:
08
02
2019
pubmed:
23
2
2019
medline:
24
12
2019
entrez:
23
2
2019
Statut:
ppublish
Résumé
Irritant contact dermatitis (ICD) is one of the most common inflammatory skin diseases caused by exposure to chemical irritants. Since chemical irritants primarily damage keratinocytes, these cells play a pivotal role in ICD. One of the phosphoinositide-metabolizing enzymes, phospholipase C (PLC) δ1, is abundantly expressed in keratinocytes. However, the role of PLCδ1 in ICD remains to be clarified. Here, we found that croton oil (CrO)-induced ear swelling, a feature of ICD, was attenuated in keratinocyte-specific PLCδ1 knockout mice (PLCδ1 cKO mice). Dendritic epidermal T cells (DETCs), which have a protective role against ICD, were activated in the epidermis of the PLCδ1 cKO mice. In addition, the skin of CrO-treated PLCδ1 cKO mice showed increased infiltration of Gr1
Identifiants
pubmed: 30791982
pii: S0006-291X(19)30233-5
doi: 10.1016/j.bbrc.2019.02.046
pii:
doi:
Substances chimiques
Phospholipase C delta
EC 3.1.4.11
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
330-335Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.