Trefoil Factor Family: Unresolved Questions and Clinical Perspectives.

Humans Trefoil Factors / metabolism
cell migration gastrointestinal wound healing lectin mucins mucosal protection mucositis

Journal

Trends in biochemical sciences
ISSN: 0968-0004
Titre abrégé: Trends Biochem Sci
Pays: England
ID NLM: 7610674

Informations de publication

Date de publication:
05 2019
Historique:
received: 19 11 2018
revised: 05 01 2019
accepted: 09 01 2019
pubmed: 23 2 2019
medline: 7 8 2019
entrez: 23 2 2019
Statut: ppublish

Résumé

The trefoil factor family of peptides (TFF1, TFF2, TFF3) with their lectin activities play important roles in mucosal protection and repair. However, major gaps in understanding their molecular function have hampered therapeutic development for gastrointestinal disorders. We provide here a critical overview of the status quo.

Identifiants

DOI: 10.1016/j.tibs.2019.01.004 PMID: 30792027 PMC: PMC6557713
pubmed: 30792027
pii: S0968-0004(19)30004-0
doi: 10.1016/j.tibs.2019.01.004
pmc: PMC6557713
mid: EMS82773
pii:
doi:

Substances chimiques

Trefoil Factors 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Pagination

387-390

Subventions

Organisme : European Research Council
ID : 714366
Pays : International

Informations de copyright

Copyright © 2019 Elsevier Ltd. All rights reserved.

Références

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Auteurs

Nayara Braga Emidio (N)

Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia; Authors contributed equally.

Werner Hoffmann (W)

Institute of Molecular Biology and Medicinal Chemistry, Otto-von-Guericke University Magdeburg, 39120 Magdeburg, Germany; Authors contributed equally.

Stuart M Brierley (SM)

Visceral Pain Research Group, Centre for Neuroscience, College of Medicine and Public Health, Flinders University, Bedford Park, South Australia, 5042, Australia; Hopwood Centre for Neurobiology and Centre for Nutrition and Gastrointestinal Diseases, Discipline of Medicine, University of Adelaide, South Australian Health and Medical Research Institute (SAHMRI), North Terrace, Adelaide, South Australia 5000, Australia.

Markus Muttenthaler (M)

Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia; Institute of Biological Chemistry, Faculty of Chemistry, University of Vienna, 1090 Vienna, Austria. Electronic address: markus.muttenthaler@univie.ac.at.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Trefoil Factor Family: Unresolved Questions...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Facteurs en trèfle › Trefoil Factor Family: Unresolved Questions...