Alkyl derivatives of 1,3,5-triazine as histamine H

Analgesics / chemical synthesis Animals Carrageenan Dose-Response Relationship, Drug Formaldehyde Humans Inflammation / chemically induced Ligands Mice Molecular Structure Rats Receptors, Histamine H4 / antagonists & inhibitors Structure-Activity Relationship Triazines / chemical synthesis
1,3,5-Triazine Docking Histamine H(4) ligands Histamine H(4) receptors Pain

Journal

Bioorganic & medicinal chemistry
ISSN: 1464-3391
Titre abrégé: Bioorg Med Chem
Pays: England
ID NLM: 9413298

Informations de publication

Date de publication:
01 04 2019
Historique:
received: 22 10 2018
revised: 31 01 2019
accepted: 11 02 2019
pubmed: 23 2 2019
medline: 28 2 2020
entrez: 23 2 2019
Statut: ppublish

Résumé

This study focuses on the design, synthesis, molecular modeling and biological evaluation of a novel group of alkyl-1,3,5-triazinyl-methylpiperazines. New compounds were synthesized and their affinities for human histamine H

Identifiants

DOI: 10.1016/j.bmc.2019.02.020 PMID: 30792106
pubmed: 30792106
pii: S0968-0896(18)31770-X
doi: 10.1016/j.bmc.2019.02.020
pii:
doi:

Substances chimiques

Analgesics 0
Ligands 0
Receptors, Histamine H4 0
Triazines 0
Formaldehyde 1HG84L3525
Carrageenan 9000-07-1

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1254-1262

Informations de copyright

Copyright © 2019 Elsevier Ltd. All rights reserved.

Auteurs

Dorota Łażewska (D)

Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College, ul. Medyczna 9, 30-688 Kraków, Poland.

Szczepan Mogilski (S)

Department of Pharmacodynamic, Faculty of Pharmacy, Jagiellonian University Medical College, ul. Medyczna 9, 30-688 Kraków, Poland.

Stefanie Hagenow (S)

Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Universitätsstr. 1, 40225 Düsseldorf, Germany.

Kamil Kuder (K)

Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College, ul. Medyczna 9, 30-688 Kraków, Poland.

Monika Głuch-Lutwin (M)

Department of Pharmacobiology, Faculty of Pharmacy, Jagiellonian University Medical College, ul. Medyczna 9, 30-688 Kraków, Poland.

Agata Siwek (A)

Department of Pharmacobiology, Faculty of Pharmacy, Jagiellonian University Medical College, ul. Medyczna 9, 30-688 Kraków, Poland.

Małgorzata Więcek (M)

Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College, ul. Medyczna 9, 30-688 Kraków, Poland.

Maria Kaleta (M)

Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College, ul. Medyczna 9, 30-688 Kraków, Poland.

Ulla Seibel (U)

Department of Pharmaceutical/Medicinal Chemistry, University of Regensburg, Universitätsstr. 31, 93053 Regensburg, Germany.

Armin Buschauer (A)

Department of Pharmaceutical/Medicinal Chemistry, University of Regensburg, Universitätsstr. 31, 93053 Regensburg, Germany.

Barbara Filipek (B)

Department of Pharmacodynamic, Faculty of Pharmacy, Jagiellonian University Medical College, ul. Medyczna 9, 30-688 Kraków, Poland.

Holger Stark (H)

Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Universitätsstr. 1, 40225 Düsseldorf, Germany.

Katarzyna Kieć-Kononowicz (K)

Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College, ul. Medyczna 9, 30-688 Kraków, Poland.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Analgésiques › Alkyl derivatives of 1,3,5-triazine as histamine H
questionsmedicales.fr › Eucaryotes › Animaux › Alkyl derivatives of 1,3,5-triazine as histamine H
questionsmedicales.fr › Glucides › Polyosides › Carragénane › Alkyl derivatives of 1,3,5-triazine as histamine H
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Relation dose-effet des médicaments › Alkyl derivatives of 1,3,5-triazine as histamine H
questionsmedicales.fr › Composés chimiques organiques › Aldéhydes › Formaldéhyde › Alkyl derivatives of 1,3,5-triazine as histamine H
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Alkyl derivatives of 1,3,5-triazine as histamine H
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Alkyl derivatives of 1,3,5-triazine as histamine H
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Ligands › Alkyl derivatives of 1,3,5-triazine as histamine H
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Alkyl derivatives of 1,3,5-triazine as histamine H
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Alkyl derivatives of 1,3,5-triazine as histamine H
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Alkyl derivatives of 1,3,5-triazine as histamine H
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs histaminergiques › Récepteur histaminergique H4 › Alkyl derivatives of 1,3,5-triazine as histamine H
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Alkyl derivatives of 1,3,5-triazine as histamine H
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Triazines › Alkyl derivatives of 1,3,5-triazine as histamine H