GLP-1 signaling suppresses menin's transcriptional block by phosphorylation in β cells.
Animals
Cyclic AMP-Dependent Protein Kinases
/ genetics
Glucagon-Like Peptide 1
/ genetics
HEK293 Cells
Humans
Insulin-Secreting Cells
/ cytology
Methyltransferases
Mice
Rats
Rats, Wistar
Repressor Proteins
Signal Transduction
Transcription Factors
/ biosynthesis
Transcription, Genetic
Transcriptional Activation
Journal
The Journal of cell biology
ISSN: 1540-8140
Titre abrégé: J Cell Biol
Pays: United States
ID NLM: 0375356
Informations de publication
Date de publication:
04 03 2019
04 03 2019
Historique:
received:
12
05
2018
revised:
23
10
2018
accepted:
07
01
2019
pubmed:
23
2
2019
medline:
11
2
2020
entrez:
23
2
2019
Statut:
ppublish
Résumé
Both menin and glucagon-like peptide 1 (GLP-1) pathways play central yet opposing role in regulating β cell function, with menin suppressing, and GLP-1 promoting, β cell function. However, little is known as to whether or how GLP-1 pathway represses menin function. Here, we show that GLP-1 signaling-activated protein kinase A (PKA) directly phosphorylates menin at the serine 487 residue, relieving menin-mediated suppression of insulin expression and cell proliferation. Mechanistically, Ser487-phosphorylated menin gains increased binding affinity to nuclear actin/myosin IIa proteins and gets sequestrated from the
Identifiants
pubmed: 30792230
pii: jcb.201805049
doi: 10.1083/jcb.201805049
pmc: PMC6400573
doi:
Substances chimiques
Men1 protein, rat
0
Repressor Proteins
0
Transcription Factors
0
Glucagon-Like Peptide 1
89750-14-1
Suv39h1 protein, rat
EC 2.1.1.
Methyltransferases
EC 2.1.1.-
Cyclic AMP-Dependent Protein Kinases
EC 2.7.11.11
Banques de données
RefSeq
['NM_001107180', 'NM_001011935']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
855-870Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK097555
Pays : United States
Informations de copyright
© 2019 Xing et al.
Références
Am J Physiol Endocrinol Metab. 2017 Aug 1;313(2):E148-E166
pubmed: 28270438
PLoS One. 2011 Jan 14;6(1):e16119
pubmed: 21264250
Physiol Genomics. 2006 Jan 12;24(2):133-43
pubmed: 16410542
J Biol Chem. 2013 Nov 15;288(46):32827-36
pubmed: 24092753
Science. 2013 May 17;340(6134):864-7
pubmed: 23558171
Trends Biochem Sci. 2013 Aug;38(8):394-402
pubmed: 23850066
Science. 2007 Jun 22;316(5832):1749-52
pubmed: 17588931
Best Pract Res Clin Endocrinol Metab. 2010 Jun;24(3):355-70
pubmed: 20833329
FEBS Lett. 2012 Oct 19;586(20):3674-80
pubmed: 22975310
Science. 1997 Apr 18;276(5311):404-7
pubmed: 9103196
Endocrinology. 2002 Jun;143(6):2303-13
pubmed: 12021195
Mol Cell Biol. 2005 May;25(9):3752-62
pubmed: 15831479
Nature. 2012 Feb 12;482(7386):542-6
pubmed: 22327296
Mol Cancer Res. 2006 Oct;4(10):793-801
pubmed: 17050672
Mol Endocrinol. 2015 Jul;29(7):988-1005
pubmed: 26061564
Mol Cell. 2004 Feb 27;13(4):587-97
pubmed: 14992727
Cell Metab. 2006 Nov;4(5):391-406
pubmed: 17084712
Recent Prog Horm Res. 1999;54:397-438; discussion 438-9
pubmed: 10548885
Cell Death Dis. 2013 Apr 11;4:e583
pubmed: 23579270
Cancer Res. 2003 Oct 1;63(19):6135-9
pubmed: 14559791
Biochim Biophys Acta. 1999 Oct 6;1447(1):51-6
pubmed: 10500243
Mol Endocrinol. 2003 Sep;17(9):1880-92
pubmed: 12819299
Cell. 2003 May 2;113(3):329-42
pubmed: 12732141
Elife. 2015 Aug 19;4:e07735
pubmed: 26287480
Diabetes. 2000 May;49(5):741-8
pubmed: 10905482
Diabetes. 2003 Jan;52(1):124-32
pubmed: 12502502
J Med Chem. 1992 Mar 20;35(6):994-1001
pubmed: 1552513
Sci Signal. 2011 Dec 13;4(203):pl2
pubmed: 22169476
Diabetologia. 2011 Nov;54(11):2741-4
pubmed: 21892687
Proc Natl Acad Sci U S A. 2006 Jan 24;103(4):1018-23
pubmed: 16415155
Proc Natl Acad Sci U S A. 2001 Jan 30;98(3):1118-23
pubmed: 11158604
Mol Biol Cell. 2013 Apr;24(7):982-94
pubmed: 23447706
Pancreas. 2004 Jul;29(1):e15-22
pubmed: 15211119
Mol Cell Biol. 2012 Sep;32(18):3610-23
pubmed: 22778134
Proc Natl Acad Sci U S A. 2012 Feb 28;109(9):E544-52
pubmed: 22323606
J Biol Chem. 2009 Apr 17;284(16):10728-36
pubmed: 19244230
Cancer Res. 2006 Jun 1;66(11):5707-15
pubmed: 16740708
Prog Mol Biol Transl Sci. 2014;121:23-65
pubmed: 24373234
Endocrinology. 2002 Jun;143(6):2437-40
pubmed: 12021209
Cancer Res. 2017 Jan 15;77(2):401-411
pubmed: 27872097
FEBS J. 2009 May;276(10):2669-85
pubmed: 19459931
Nucleic Acids Res. 2013 Oct;41(19):9152-67
pubmed: 23921630
Exp Diabetes Res. 2010;2010:876701
pubmed: 21318185
J Biol Chem. 2011 Sep 9;286(36):31742-8
pubmed: 21757704
Proc Natl Acad Sci U S A. 2010 Nov 23;107(47):20358-63
pubmed: 21059956
Mol Cell Biol. 2003 Sep;23(17):6075-85
pubmed: 12917331
Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14659-64
pubmed: 16195383
Cell. 1999 Jan 8;96(1):143-52
pubmed: 9989505
Gastroenterology. 2017 Dec;153(6):1555-1567.e15
pubmed: 28859856