Underdevelopment of the Human Hippocampus in Callosal Agenesis: An In Vivo Fetal MRI Study.
Journal
AJNR. American journal of neuroradiology
ISSN: 1936-959X
Titre abrégé: AJNR Am J Neuroradiol
Pays: United States
ID NLM: 8003708
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
20
09
2018
accepted:
14
01
2019
pubmed:
23
2
2019
medline:
10
3
2020
entrez:
23
2
2019
Statut:
ppublish
Résumé
In subjects with agenesis of the corpus callosum, a variety of structural brain alterations is already present during prenatal life. Quantification of these alterations in fetuses with associated brain or body malformations (corpus callosum agenesis and other related anomalies) and so-called isolated cases may help to optimize the challenging prognostic prenatal assessment of fetuses with corpus callosum agenesis. This fetal MR imaging study aimed to identify differences in the size of the prenatal hippocampus between subjects with isolated corpus callosum agenesis, corpus callosum agenesis and other related anomalies, and healthy controls. Eighty-five in utero fetal brain MR imaging scans, (20-35 gestational weeks) were postprocessed using a high-resolution algorithm. On the basis of multiplanar T2-TSE sequences, 3D isovoxel datasets were generated, and both hippocampi and the intracranial volume were segmented. Hippocampal volumes increased linearly with gestational weeks in all 3 groups. One-way ANOVA demonstrated differences in hippocampal volumes between control and pathologic groups (isolated corpus callosum agenesis: left, Callosal agenesis apparently interferes with the normal process of hippocampal formation and growth, resulting in underdevelopment, which could account for certain learning and memory deficits in individuals with agenesis of the corpus callosum in later life.
Sections du résumé
BACKGROUND AND PURPOSE
In subjects with agenesis of the corpus callosum, a variety of structural brain alterations is already present during prenatal life. Quantification of these alterations in fetuses with associated brain or body malformations (corpus callosum agenesis and other related anomalies) and so-called isolated cases may help to optimize the challenging prognostic prenatal assessment of fetuses with corpus callosum agenesis. This fetal MR imaging study aimed to identify differences in the size of the prenatal hippocampus between subjects with isolated corpus callosum agenesis, corpus callosum agenesis and other related anomalies, and healthy controls.
MATERIALS AND METHODS
Eighty-five in utero fetal brain MR imaging scans, (20-35 gestational weeks) were postprocessed using a high-resolution algorithm. On the basis of multiplanar T2-TSE sequences, 3D isovoxel datasets were generated, and both hippocampi and the intracranial volume were segmented.
RESULTS
Hippocampal volumes increased linearly with gestational weeks in all 3 groups. One-way ANOVA demonstrated differences in hippocampal volumes between control and pathologic groups (isolated corpus callosum agenesis: left,
CONCLUSIONS
Callosal agenesis apparently interferes with the normal process of hippocampal formation and growth, resulting in underdevelopment, which could account for certain learning and memory deficits in individuals with agenesis of the corpus callosum in later life.
Identifiants
pubmed: 30792247
pii: ajnr.A5986
doi: 10.3174/ajnr.A5986
pmc: PMC7028671
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
576-581Informations de copyright
© 2019 by American Journal of Neuroradiology.
Références
J Comp Neurol. 1996 Apr 01;367(2):293-307
pubmed: 8708011
Pediatr Res. 2011 May;69(5 Pt 1):425-9
pubmed: 21270675
Neuropsychologia. 2016 Jun;86:183-92
pubmed: 27091586
Neuroimage. 2012 Feb 1;59(3):2255-65
pubmed: 21985910
Nat Commun. 2014 Apr 17;5:3708
pubmed: 24739528
Nat Rev Neurosci. 2007 Apr;8(4):287-99
pubmed: 17375041
Neuropsychologia. 2014 Jul;60:121-30
pubmed: 24933663
Neuroscience. 1989;30(1):105-16
pubmed: 2747906
Neuroimage. 2015 Oct 1;119:33-43
pubmed: 26123377
Braz J Med Biol Res. 2002 Dec;35(12):1431-9
pubmed: 12436186
J Comp Neurol. 1961 Dec;117:371-82
pubmed: 14468243
J Comp Neurol. 2007 Jan 10;500(2):239-54
pubmed: 17111359
J Neurosci. 2001 Apr 15;21(8):2749-58
pubmed: 11306627
Clin Genet. 2004 Oct;66(4):276-89
pubmed: 15355427
Prog Neuropsychopharmacol Biol Psychiatry. 1999 May;23(4):571-88
pubmed: 10390717
Childs Nerv Syst. 2009 Aug;25(8):933-9
pubmed: 19212765
Neuroimage. 2016 Jan 15;125:456-478
pubmed: 26499811
AJNR Am J Neuroradiol. 1995 Oct;16(9):1847-53
pubmed: 8693985
J Comp Neurol. 2001 May 28;434(2):147-57
pubmed: 11331522
Genes Brain Behav. 2012 Oct;11(7):757-66
pubmed: 22537318
Nat Rev Neurosci. 2005 Dec;6(12):955-65
pubmed: 16288299
Radiology. 1986 Aug;160(2):355-62
pubmed: 3726113
Eur Radiol. 2003 Mar;13(3):598-604
pubmed: 12594564
Comput Methods Programs Biomed. 2013 Jan;109(1):65-73
pubmed: 23036854
J Comp Neurol. 1968 Jan;132(1):45-72
pubmed: 5293999
J Comp Neurol. 1996 Apr 01;367(2):274-92
pubmed: 8708010
Brain Res Bull. 2002 Aug 15;58(4):411-6
pubmed: 12183019
AJNR Am J Neuroradiol. 2001 Feb;22(2):389-93
pubmed: 11156788
Cereb Cortex. 2014 May;24(5):1138-51
pubmed: 23302812
AJNR Am J Neuroradiol. 1992 Jan-Feb;13(1):115-22
pubmed: 1595428
Dev Biol. 2012 May 1;365(1):36-49
pubmed: 22349628
AJNR Am J Neuroradiol. 2009 Jun;30(6):1142-8
pubmed: 19246528
Neuroimage. 2006 Jul 1;31(3):1116-28
pubmed: 16545965
Neuropsychologia. 2015 Oct;77:359-65
pubmed: 26384774