Effect of chain flexibility on cell adhesion: Semi-flexible model-based analysis of cell adhesion to hydrogels.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
21 02 2019
21 02 2019
Historique:
received:
14
11
2018
accepted:
15
01
2019
entrez:
23
2
2019
pubmed:
23
2
2019
medline:
29
8
2020
Statut:
epublish
Résumé
Hydrogels have been developed and applied to various biomedical applications due to their biocompatibility. However, understanding of modulation between cells to hydrogel interface is still unclear, and parameters to explain the interaction are not sophisticated enough. In this report, we studied the effect of polymer chain flexibility on cell adhesion to various hydrogel constructs of collagen and fibrin gels. Specifically, novel method of semi-flexible model-based analysis confirmed that chain flexibility mediated microstructure of the hydrogels is a critical factor for cell adhesion on their surfaces. The proposed analysis showed possibility of more accurate prediction of biocompatibility of hydrogels, and it should be considered as one of the important criteria for polymer design and selections for enhancing both biocompatibility and biofunctionality.
Identifiants
pubmed: 30792420
doi: 10.1038/s41598-019-38951-7
pii: 10.1038/s41598-019-38951-7
pmc: PMC6385503
doi:
Substances chimiques
Biocompatible Materials
0
Hydrogels
0
Fibrin
9001-31-4
Collagen
9007-34-5
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2463Références
Science. 2005 Nov 18;310(5751):1139-43
pubmed: 16293750
J Biomed Mater Res B Appl Biomater. 2015 Feb;103(2):397-406
pubmed: 24895116
FASEB J. 2013 Apr;27(4):1351-61
pubmed: 23254340
Sci Rep. 2015 Nov 27;5:17225
pubmed: 26611125
Phys Rev Lett. 1995 Dec 11;75(24):4425-4428
pubmed: 10059905
Int J Mol Sci. 2015 Aug 05;16(8):18149-84
pubmed: 26251901
Biophys J. 2010 May 19;98(10):2281-9
pubmed: 20483337
J Mater Chem B. 2017 Apr 14;5(14):2671-2678
pubmed: 32264046
Nat Commun. 2015 Apr 28;6:6933
pubmed: 25917746
Tissue Eng Part A. 2010 Aug;16(8):2675-85
pubmed: 20387987
Cell Commun Adhes. 2015 Apr - Dec;22(2-6):79-89
pubmed: 27960555
J Biomed Mater Res B Appl Biomater. 2008 Nov;87(2):415-24
pubmed: 18435405
Cell Biochem Biophys. 2007;49(3):165-81
pubmed: 17952642
Cell Adh Migr. 2016 Sep 2;10(5):495-504
pubmed: 26910190
Hepatology. 2008 Apr;47(4):1394-400
pubmed: 18307210
ACS Appl Mater Interfaces. 2016 Aug 31;8(34):21946-55
pubmed: 27128771
Tissue Eng Part B Rev. 2011 Jun;17(3):155-64
pubmed: 21303220
Cell Adh Migr. 2018;12(5):472-488
pubmed: 29969940
Science. 2004 May 28;304(5675):1301-5
pubmed: 15166374
Soft Matter. 2008 May 14;4(6):1133-1140
pubmed: 32907251
J Vis Exp. 2011 Aug 28;(54):
pubmed: 21897356
Nat Rev Mol Cell Biol. 2009 Jan;10(1):21-33
pubmed: 19197329
Mater Sci Eng C Mater Biol Appl. 2017 Jan 1;70(Pt 2):1163-1175
pubmed: 27772718
Nat Mater. 2012 Sep;11(9):768-74
pubmed: 22751181
ACS Macro Lett. 2017 Jul 18;6(7):657-662
pubmed: 35650867
Acta Biomater. 2011 Apr;7(4):1627-33
pubmed: 21130186