Adenosine A2A Receptor Stimulation Inhibits TCR-Induced Notch1 Activation in CD8+T-Cells.
A2A adenosine receptor (A2AR)
CD8+T-cells
Notch1
adenosine
immunosuppression
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2019
2019
Historique:
received:
12
10
2018
accepted:
18
01
2019
entrez:
23
2
2019
pubmed:
23
2
2019
medline:
23
2
2019
Statut:
epublish
Résumé
Notch receptors signaling is required for optimal T-cell activation and function. T-cell receptor (TCR) engagement can activate Notch receptors in T-cells in a ligand-independent fashion. In this study, we examined the role of adenosine A2A receptor (A2AR) signaling pathway in regulating the activity of Notch1 induced by TCR stimulation in CD8+T-cells. A selective A2AR agonist decreased Notch1 protein expression and Notch1 cleavage, and reduced transcripts of Notch1-target genes
Identifiants
pubmed: 30792717
doi: 10.3389/fimmu.2019.00162
pmc: PMC6374329
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
162Subventions
Organisme : NCI NIH HHS
ID : P01 CA166009
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA184185
Pays : United States
Organisme : NCI NIH HHS
ID : R21 CA162133
Pays : United States
Organisme : NIGMS NIH HHS
ID : U54 GM104940
Pays : United States
Commentaires et corrections
Type : ErratumIn
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