Conservative treatment for well-differentiated endometrial cancer: when and why it should be considered in young women.
conservative treatment
endometrial cancer
fertility-sparing treatment
hysteroscopic resection
Journal
Ecancermedicalscience
ISSN: 1754-6605
Titre abrégé: Ecancermedicalscience
Pays: England
ID NLM: 101392236
Informations de publication
Date de publication:
2019
2019
Historique:
received:
17
10
2018
entrez:
23
2
2019
pubmed:
23
2
2019
medline:
23
2
2019
Statut:
epublish
Résumé
The aim of this review was to update current knowledge on the conservative treatment of endometrial cancer (EC) based on a literature review. A web-based search in the MEDLINE database was carried out on EC management and treatment. All relevant information has been collected and analysed. Case series were mainly found in the literature search. Conservative treatments were offered to young patients with stage I low-grade endometrioid carcinomas of the endometrium. Different options included high/low dose progestin treatments, hysteroscopic resection of the disease, a levonorgestrel intrauterine device or a combination of various strategies. The overall complete response rate was near 76.5% with a recurrence rate of up to 33.8%. Pregnancy outcomes reached rates of 64.8% for live births. The current clinical outcomes show that conservative treatment aimed at preserving fertility is feasible for stage I endometrial well-differentiated adenocarcinomas in motivated patients under close monitoring.
Identifiants
pubmed: 30792809
doi: 10.3332/ecancer.2019.892
pii: can-13-892
pmc: PMC6369973
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
892Références
Eur J Gynaecol Oncol. 2000;21(1):95-7
pubmed: 10726632
J Magn Reson Imaging. 2000 Sep;12(3):460-6
pubmed: 10992314
AJR Am J Roentgenol. 2001 Mar;176(3):603-6
pubmed: 11222188
Cancer Lett. 2001 Jun 10;167(1):39-48
pubmed: 11323097
Eur J Gynaecol Oncol. 2001;22(3):217-20
pubmed: 11501776
Eur J Obstet Gynecol Reprod Biol. 2001 Sep;98(1):53-7
pubmed: 11516800
Am J Obstet Gynecol. 2002 Apr;186(4):651-7
pubmed: 11967486
Cancer. 2002 Apr 15;94(8):2192-8
pubmed: 12001117
Fertil Steril. 2003 Dec;80(6):1315-24
pubmed: 14667859
Gynecol Oncol. 2003 Dec;91(3):569-72
pubmed: 14675678
Gynecol Oncol. 2004 Oct;95(1):133-8
pubmed: 15385122
Gynecol Oncol. 2005 Jun;97(3):740-50
pubmed: 15885761
Gynecol Oncol. 2005 Oct;99(1):215-7
pubmed: 15979130
Recent Results Cancer Res. 1992;124:69-73
pubmed: 1615220
Obstet Gynecol. 2005 Oct;106(4):693-9
pubmed: 16199623
Int J Gynecol Cancer. 2006 Jan-Feb;16 Suppl 1:442-5
pubmed: 16515642
J Minim Invasive Gynecol. 2007 Jan-Feb;14(1):119-22
pubmed: 17218243
Hum Reprod. 2007 Jul;22(7):1953-8
pubmed: 17449880
J Minim Invasive Gynecol. 2008 Jan-Feb;15(1):87-91
pubmed: 18262151
Clin Transl Oncol. 2008 Mar;10(3):155-62
pubmed: 18321818
Int J Gynecol Cancer. 2008 Mar-Apr;18(2):269-73
pubmed: 18334008
Gynecol Oncol. 2009 Sep;114(3):448-51
pubmed: 19560801
Eur J Gynaecol Oncol. 2009;30(3):313-6
pubmed: 19697629
Fertil Steril. 2010 Mar 1;93(4):1286-9
pubmed: 19700153
Fertil Steril. 2010 Jan;93(1):283-5
pubmed: 19962142
Steroids. 2010 Dec;75(12):912-7
pubmed: 20566359
J Minim Invasive Gynecol. 2010 Jul-Aug;17(4):436-48
pubmed: 20621007
Ann Oncol. 2011 Mar;22(3):643-9
pubmed: 20876910
Case Rep Oncol. 2010 Oct 25;3(3):380-385
pubmed: 21113347
Anticancer Res. 2014 May;34(5):2497-502
pubmed: 24778066
J Cancer Prev. 2013 Dec;18(4):313-21
pubmed: 25337560
Ecancermedicalscience. 2015 Feb 03;9:505
pubmed: 25729418
Ann Oncol. 2016 Jan;27(1):16-41
pubmed: 26634381
Eur J Gynaecol Oncol. 2016;37(1):6-12
pubmed: 27048101
Am J Obstet Gynecol. 2018 Jan;218(1):75-87
pubmed: 28599899
J Gynecol Oncol. 2017 Nov;28(6):e86
pubmed: 29027404
Cancer. 1987 Oct 15;60(8 Suppl):2035-41
pubmed: 3652025
Obstet Gynecol. 1986 Dec;68(6):741-5
pubmed: 3785784
Obstet Gynecol. 1985 Jul;66(1):106-10
pubmed: 4011061
Obstet Gynecol. 1984 Sep;64(3):417-20
pubmed: 6462572
Obstet Gynecol. 1981 Jun;57(6):699-704
pubmed: 7015203
Gynecol Oncol. 1995 Aug;58(2):255-7
pubmed: 7622115
J Clin Endocrinol Metab. 1993 Dec;77(6):1458-64
pubmed: 8263128
AJR Am J Roentgenol. 1993 Sep;161(3):595-9
pubmed: 8352114
AJR Am J Roentgenol. 1993 Mar;160(3):533-8
pubmed: 8430547
Obstet Gynecol. 1997 Sep;90(3):434-40
pubmed: 9277658
Cancer. 1998 Jul 1;83(1):111-21
pubmed: 9655300