Global connectivity of the fronto-parietal cognitive control network is related to depression symptoms in the general population.
Depression
Fronto-parietal network
Functional connectivity
fMRI
Journal
Network neuroscience (Cambridge, Mass.)
ISSN: 2472-1751
Titre abrégé: Netw Neurosci
Pays: United States
ID NLM: 101719149
Informations de publication
Date de publication:
2019
2019
Historique:
received:
25
01
2018
accepted:
04
04
2018
entrez:
23
2
2019
pubmed:
23
2
2019
medline:
23
2
2019
Statut:
epublish
Résumé
We all vary in our mental health, even among people not meeting diagnostic criteria for mental illness. Understanding this individual variability may reveal factors driving the risk for mental illness, as well as factors driving subclinical problems that still adversely affect quality of life. To better understand the large-scale brain network mechanisms underlying this variability, we examined the relationship between mental health symptoms and resting-state functional connectivity patterns in cognitive control systems. One such system is the fronto-parietal cognitive control network (FPN). Changes in FPN connectivity may impact mental health by disrupting the ability to regulate symptoms in a goal-directed manner. Here we test the hypothesis that FPN dysconnectivity relates to mental health symptoms even among individuals who do not meet formal diagnostic criteria but may exhibit meaningful symptom variation. We found that depression symptoms severity negatively correlated with between-network global connectivity (BGC) of the FPN. This suggests that decreased connectivity between the FPN and the rest of the brain is related to increased depression symptoms in the general population. These findings complement previous clinical studies to support the hypothesis that global FPN connectivity contributes to the regulation of mental health symptoms across both health and disease.
Identifiants
pubmed: 30793076
doi: 10.1162/netn_a_00056
pii: netn_a_00056
pmc: PMC6326740
doi:
Types de publication
Journal Article
Langues
eng
Pagination
107-123Subventions
Organisme : NIMH NIH HHS
ID : R01 MH108590
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH112189
Pays : United States
Organisme : NIMH NIH HHS
ID : R03 MH105765
Pays : United States
Déclaration de conflit d'intérêts
Competing Interests: The authors have declared that no competing interests exist.
Références
Psychol Assess. 2004 Dec;16(4):360-72
pubmed: 15584795
Brain Res Cogn Brain Res. 2005 Dec;25(3):607-23
pubmed: 16242923
Biol Psychiatry. 2007 Sep 1;62(5):429-37
pubmed: 17210143
Neuroimage. 2007 Aug 1;37(1):343-60
pubmed: 17553704
Proc Natl Acad Sci U S A. 2007 Jun 26;104(26):11073-8
pubmed: 17576922
Soc Cogn Affect Neurosci. 2007 Dec;2(4):303-12
pubmed: 18985136
Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):1942-7
pubmed: 19171889
J Neurosci. 2009 Feb 11;29(6):1860-73
pubmed: 19211893
Neuroimage. 2010 Feb 15;49(4):3132-48
pubmed: 19909818
Psychiatry Res. 2010 Apr 30;176(2-3):183-9
pubmed: 20138370
J Cogn Neurosci. 2011 Jan;23(1):168-82
pubmed: 20146600
Trends Cogn Sci. 2010 Apr;14(4):172-9
pubmed: 20171926
PLoS Comput Biol. 2010 Jun 10;6(6):e1000808
pubmed: 20548945
Psychiatry Res. 2011 Mar 30;186(1):128-32
pubmed: 20843557
MMWR Morb Mortal Wkly Rep. 2010 Oct 1;59(38):1229-35
pubmed: 20881934
Front Syst Neurosci. 2010 Sep 20;4:null
pubmed: 20941370
Biol Psychiatry. 2011 Aug 15;70(4):327-33
pubmed: 21459364
Ann N Y Acad Sci. 2011 Apr;1224:126-146
pubmed: 21486299
Biol Psychiatry. 2011 Jul 1;70(1):43-50
pubmed: 21496789
Biol Psychiatry. 2011 Jul 1;70(1):64-72
pubmed: 21514570
J Neurophysiol. 2011 Sep;106(3):1125-65
pubmed: 21653723
Neuroimage. 2012 Feb 1;59(3):2142-54
pubmed: 22019881
Neuron. 2011 Nov 17;72(4):665-78
pubmed: 22099467
J Affect Disord. 2012 Jun;139(1):56-65
pubmed: 22425432
Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):5464-8
pubmed: 22431642
Assessment. 2012 Sep;19(3):354-69
pubmed: 22605785
Trends Neurosci. 2012 Sep;35(9):527-35
pubmed: 22658924
Hum Brain Mapp. 2014 Feb;35(2):483-91
pubmed: 23033154
Biol Psychiatry. 2013 Jul 1;74(1):48-54
pubmed: 23273724
Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1929-34
pubmed: 23319644
Front Psychiatry. 2013 Mar 01;4:10
pubmed: 23459749
PLoS One. 2013;8(3):e58067
pubmed: 23469262
Neuroimage. 2013 Oct 15;80:105-24
pubmed: 23668970
Neuroimage. 2013 Oct 15;80:62-79
pubmed: 23684880
Cereb Cortex. 2014 Nov;24(11):2981-90
pubmed: 23765157
Nat Neurosci. 2013 Sep;16(9):1348-55
pubmed: 23892552
Stress Health. 2015 Feb;31(1):63-70
pubmed: 23897800
Neuron. 2013 Aug 21;79(4):798-813
pubmed: 23972601
Neuroimage. 2014 Feb 15;87:345-55
pubmed: 24220041
JAMA Psychiatry. 2014 Feb;71(2):109-18
pubmed: 24306091
Front Hum Neurosci. 2014 Jan 21;7:930
pubmed: 24478665
Neuroscientist. 2014 Dec;20(6):652-64
pubmed: 24622818
Radiology. 2014 Aug;272(2):514-23
pubmed: 24785156
J Psychiatr Res. 2014 Dec;59:38-44
pubmed: 25277274
Cereb Cortex. 2016 Jan;26(1):288-303
pubmed: 25316338
Front Behav Neurosci. 2014 Oct 02;8:346
pubmed: 25324749
Hum Brain Mapp. 2015 Feb;36(2):768-78
pubmed: 25332057
Biol Psychiatry. 2015 Feb 1;77(3):223-235
pubmed: 25444171
PLoS One. 2014 Dec 12;9(12):e114603
pubmed: 25502215
JAMA Psychiatry. 2015 Jun;72(6):603-11
pubmed: 25785575
Transl Psychiatry. 2015 Nov 17;5:e683
pubmed: 26575224
Proc Natl Acad Sci U S A. 2016 Jan 12;113(2):E219-28
pubmed: 26699491
Hum Brain Mapp. 2016 Sep;37(9):3214-23
pubmed: 27144347
Nature. 2016 Aug 11;536(7615):171-178
pubmed: 27437579
Cereb Cortex. 2017 Sep 1;27(9):4492-4502
pubmed: 27550863
Neuropsychopharmacology. 2017 May;42(6):1210-1219
pubmed: 27604566
Front Hum Neurosci. 2016 Nov 09;10:565
pubmed: 27881961
Nat Med. 2017 Jan;23(1):28-38
pubmed: 27918562
J Psychiatr Res. 2017 Sep;92:147-159
pubmed: 28458140
Elife. 2017 May 30;6:
pubmed: 28555565
Nat Commun. 2017 Oct 18;8(1):1027
pubmed: 29044112
Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):E1598-E1607
pubmed: 29382744
Neuroimage. 2019 Jan 15;185:35-57
pubmed: 30291974
Magn Reson Med. 1995 Oct;34(4):537-41
pubmed: 8524021