Bronchopulmonary dysplasia in very preterm infants: Outcome up to preschool age, in a single center of Austria.
Austria
Bronchopulmonary Dysplasia
/ complications
Child Development
Child, Preschool
Cohort Studies
Female
Follow-Up Studies
Humans
Incidence
Infant
Infant, Newborn
Infant, Premature
Intensive Care Units, Neonatal
Male
Neurodevelopmental Disorders
/ epidemiology
Respiration, Artificial
/ statistics & numerical data
Respiratory Tract Infections
/ epidemiology
Retrospective Studies
bronchopulmonary dysplasia
growth
morbidity
neurodevelopment
preterm infant
Journal
Pediatrics international : official journal of the Japan Pediatric Society
ISSN: 1442-200X
Titre abrégé: Pediatr Int
Pays: Australia
ID NLM: 100886002
Informations de publication
Date de publication:
Apr 2019
Apr 2019
Historique:
received:
06
07
2018
revised:
26
11
2018
accepted:
09
01
2019
pubmed:
23
2
2019
medline:
11
5
2019
entrez:
23
2
2019
Statut:
ppublish
Résumé
Bronchopulmonary dysplasia (BPD) is the most frequent chronic lung disease in infancy and is associated with neonatal comorbidity and impairment in pulmonary and neurodevelopmental (ND) long-term outcome. This was a retrospective, single-center, cohort study to compare a cohort of very preterm infants (gestational age [GA], 24 Bronchopulmonary dysplasia (incidence, 11.3%) was associated with a higher rate of neonatal pneumonia (26% vs 7%, P = 0.001), longer total duration of mechanical ventilation (mean days, 21 vs 13, P < 0.001), and a higher rate of pulmonary hypertension (20.5% vs 0%, P = 0.002) and of severe retinopathy of prematurity (13.6% vs 0%, P = 0.026). Incidence of LRTI was significantly higher in the BPD infants (50% vs 26%, P = 0.025). ND outcome did not differ between the two groups. Growth at neonatal intensive care unit discharge was similar. In the BPD cohort, rate of weight < 10th percentile was higher at 2 years' CA (52% vs 30%, P = 0.041) and rate of head circumference < 10th percentile was higher at preschool age (59% vs 27%, P = 0.028). Neonatal respiratory morbidity was significantly higher in the BPD cohort, but long-term ND outcome did not differ. Infants with BPD had poorer growth.
Sections du résumé
BACKGROUND
BACKGROUND
Bronchopulmonary dysplasia (BPD) is the most frequent chronic lung disease in infancy and is associated with neonatal comorbidity and impairment in pulmonary and neurodevelopmental (ND) long-term outcome.
METHODS
METHODS
This was a retrospective, single-center, cohort study to compare a cohort of very preterm infants (gestational age [GA], 24
RESULTS
RESULTS
Bronchopulmonary dysplasia (incidence, 11.3%) was associated with a higher rate of neonatal pneumonia (26% vs 7%, P = 0.001), longer total duration of mechanical ventilation (mean days, 21 vs 13, P < 0.001), and a higher rate of pulmonary hypertension (20.5% vs 0%, P = 0.002) and of severe retinopathy of prematurity (13.6% vs 0%, P = 0.026). Incidence of LRTI was significantly higher in the BPD infants (50% vs 26%, P = 0.025). ND outcome did not differ between the two groups. Growth at neonatal intensive care unit discharge was similar. In the BPD cohort, rate of weight < 10th percentile was higher at 2 years' CA (52% vs 30%, P = 0.041) and rate of head circumference < 10th percentile was higher at preschool age (59% vs 27%, P = 0.028).
CONCLUSION
CONCLUSIONS
Neonatal respiratory morbidity was significantly higher in the BPD cohort, but long-term ND outcome did not differ. Infants with BPD had poorer growth.
Identifiants
pubmed: 30793436
doi: 10.1111/ped.13815
pmc: PMC6850710
doi:
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
381-387Informations de copyright
© 2019 The Authors. Pediatrics International published by John Wiley & Sons Australia, Ltd on behalf of Japan Pediatric Society.
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