Relation between resting sympathetic outflow and vasoconstrictor responses to sympathetic nerve bursts: sex differences in healthy young adults.
blood pressure
muscle sympathetic nerve activity
sex differences
vascular physiology
vasoconstriction
Journal
American journal of physiology. Regulatory, integrative and comparative physiology
ISSN: 1522-1490
Titre abrégé: Am J Physiol Regul Integr Comp Physiol
Pays: United States
ID NLM: 100901230
Informations de publication
Date de publication:
01 05 2019
01 05 2019
Historique:
pubmed:
23
2
2019
medline:
20
2
2020
entrez:
23
2
2019
Statut:
ppublish
Résumé
Previous studies have demonstrated an inverse relation between resting muscle sympathetic nerve activity (MSNA) and vasoconstrictor responsiveness (i.e., sympathetic transduction), such that those with high resting MSNA have low vascular responsiveness, and vice versa. The purpose of this investigation was to determine whether biological sex influences the balance between resting MSNA and beat-to-beat sympathetic transduction. We measured blood pressure (BP) and MSNA during supine rest in 54 healthy young adults (27 females: 23 ± 4 yr, 107 ± 8/63 ± 8 mmHg; 27 males: 25 ± 3 yr, 115 ± 11/64 ± 7 mmHg; means ± SD). We quantified beat-to-beat fluctuations in mean arterial pressure (MAP, mmHg) and limb vascular conductance (LVC, %) for 10 cardiac cycles after each MSNA burst using signal averaging, an index of sympathetic vascular transduction. In females, there was no correlation between resting MSNA (burst incidence; burst/100 heartbeats) and peak ΔMAP (
Identifiants
pubmed: 30794437
doi: 10.1152/ajpregu.00305.2018
pmc: PMC6589599
doi:
Types de publication
Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
R463-R471Subventions
Organisme : NIGMS NIH HHS
ID : P20 GM113125
Pays : United States
Références
Hypertension. 1993 Apr;21(4):498-503
pubmed: 8458648
J Hypertens. 2010 Apr;28(4):660-4
pubmed: 20625246
J Physiol. 2011 Nov 1;589(Pt 21):5285-97
pubmed: 21859824
Curr Hypertens Rep. 2014 Sep;16(9):470
pubmed: 25097109
Hypertension. 2009 Jul;54(1):127-33
pubmed: 19470875
Am J Physiol Regul Integr Comp Physiol. 2016 Dec 1;311(6):R1271-R1275
pubmed: 27856414
J Am Heart Assoc. 2017 Oct 19;6(10):
pubmed: 29051214
J Physiol. 2011 Jul 1;589(Pt 13):3395-404
pubmed: 21540345
J Appl Physiol (1985). 1989 May;66(5):2472-8
pubmed: 2745308
J Neurophysiol. 2018 Apr 1;119(4):1257-1265
pubmed: 29357474
J Physiol. 2005 Oct 1;568(Pt 1):315-21
pubmed: 16037092
J Physiol. 1978 Jan;274:621-37
pubmed: 625012
Circulation. 2002 Sep 10;106(11):1349-54
pubmed: 12221051
Am J Physiol Heart Circ Physiol. 2017 May 1;312(5):H1031-H1051
pubmed: 28364017
J Auton Nerv Syst. 1982 Nov;6(3):293-302
pubmed: 7169499
Clin Auton Res. 1993 Jun;3(3):201-5
pubmed: 8400820
J Physiol. 1977 Nov;272(2):383-97
pubmed: 592196
J Physiol. 2013 Jul 15;591(14):3637-49
pubmed: 23652594
Exp Physiol. 2013 Oct;98(10):1422-31
pubmed: 23733520
Physiology (Bethesda). 2014 Jan;29(1):8-15
pubmed: 24382867
Am J Physiol Heart Circ Physiol. 2012 Jun 1;302(11):H2419-27
pubmed: 22427525
Auton Neurosci. 2015 Dec;193:12-21
pubmed: 26299824
Physiol Rep. 2014 Jun 06;2(6):
pubmed: 24907296
J Physiol. 2004 Apr 15;556(Pt 2):545-55
pubmed: 14766944
Am J Physiol Heart Circ Physiol. 2013 Mar 1;304(5):H759-66
pubmed: 23292718
J Physiol. 2006 May 1;572(Pt 3):821-7
pubmed: 16513672
Hypertension. 1991 Jan;17(1):36-43
pubmed: 1986981
J Am Coll Cardiol. 2000 Oct;36(4):1233-8
pubmed: 11028476
J Neurophysiol. 2018 May 1;119(5):1731-1744
pubmed: 29412776
Crit Care. 2002 Feb;6(1):66-71
pubmed: 11940268
Am J Physiol Heart Circ Physiol. 2001 Nov;281(5):H2028-35
pubmed: 11668064
Behav Res Methods. 2007 May;39(2):175-91
pubmed: 17695343
Hypertension. 2005 Apr;45(4):522-5
pubmed: 15767469
Stroke. 2018 Jan;49(1):62-67
pubmed: 29229726
Hypertension. 2018 Jan;71(1):192-198
pubmed: 29203629
J Physiol. 2004 Dec 1;561(Pt 2):583-96
pubmed: 15486013
J Physiol. 2012 May 1;590(9):2069-79
pubmed: 22351633
Circulation. 2000 Feb 29;101(8):862-8
pubmed: 10694525
Circulation. 2005 Feb 1;111(4):494-8
pubmed: 15687139
Am J Physiol Heart Circ Physiol. 2018 Aug 1;315(2):H303-H313
pubmed: 30028200