Antimicrobial guaianolide sesquiterpenoids from leaves of the Saudi Arabian plant Anvillea garcinii.

Anti-Bacterial Agents / isolation & purification Antifungal Agents / isolation & purification Asteraceae / chemistry Microbial Sensitivity Tests Molecular Structure Phytochemicals / isolation & purification Plant Leaves / chemistry Plants, Medicinal / chemistry Saudi Arabia Sesquiterpenes, Guaiane / isolation & purification
Antimicrobial activity Anvillea garcinii Guaianolide Sesquiterpenes

Journal

Fitoterapia
ISSN: 1873-6971
Titre abrégé: Fitoterapia
Pays: Netherlands
ID NLM: 16930290R

Informations de publication

Date de publication:
Apr 2019
Historique:
received: 04 02 2019
revised: 14 02 2019
accepted: 18 02 2019
pubmed: 23 2 2019
medline: 23 7 2019
entrez: 23 2 2019
Statut: ppublish

Résumé

Anvillea garcinii is a medicinal plant used in the Arab region for intestinal diseases, lungs and liver diseases, digestive problems, and as an anti-diabetic. Repeated chromatographic purifications of A. garcinii leaves led to the isolation of two undescribed guaiane sesquiterpene lactones (1-2), along with four known germacranolides (3-6). The structures of the new compounds were established using spectroscopic (1D, 2D NMR) and spectrometric methods (ESIMS). Compounds 1 and 2 were shown to possess hydroxyl substituents at position 9, a structural feature rarely reported in guaianolide-type sesquiterpenes. The antimicrobial activity of 1-6 was screened against five different gram-positive/negative bacteria and the fungi Candida albicans and C. parapsilosis. Compounds 1 and 2 displayed remarkable antifungal effect against C. albicans and C. parapsilosis and potent antibacterial activities against Staphylococcus aureus.

Identifiants

DOI: 10.1016/j.fitote.2019.02.017 PMID: 30794919
pubmed: 30794919
pii: S0367-326X(19)30264-3
doi: 10.1016/j.fitote.2019.02.017
pii:
doi:

Substances chimiques

Anti-Bacterial Agents 0
Antifungal Agents 0
Phytochemicals 0
Sesquiterpenes, Guaiane 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

129-134

Informations de copyright

Copyright © 2019 Elsevier B.V. All rights reserved.

Auteurs

Shagufta Perveen (S)

Department of Pharmacognosy, College of Pharmacy, King Saud University, 22452, Riyadh 11495, Saudi Arabia. Electronic address: shagufta792000@yahoo.com.

Jawaher Alqahtani (J)

Department of Pharmacognosy, College of Pharmacy, King Saud University, 22452, Riyadh 11495, Saudi Arabia; Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, 80131 Naples, Italy.

Raha Orfali (R)

Department of Pharmacognosy, College of Pharmacy, King Saud University, 22452, Riyadh 11495, Saudi Arabia.

Areej Mohammad Al-Taweel (AM)

Department of Pharmacognosy, College of Pharmacy, King Saud University, 22452, Riyadh 11495, Saudi Arabia.

Hasan Soliman Yusufoglu (HS)

Department of Pharmacognosy, College of Pharmacy, Prince Sattam Bin Abdulaziz University, 173, Al-Kharj 11942, Saudi Arabia.

Maged Saad Abdel-Kader (MS)

Department of Pharmacognosy, College of Pharmacy, Prince Sattam Bin Abdulaziz University, 173, Al-Kharj 11942, Saudi Arabia; Department of Pharmacognosy, Faculty of Pharmacy, Alexandria University, Alexandria 21215, Egypt.

Orazio Taglialatela-Scafati (O)

Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, 80131 Naples, Italy. Electronic address: scatagli@unina.it.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Antimicrobial guaianolide sesquiterpenoids...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antifongiques › Antimicrobial guaianolide sesquiterpenoids...
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Asteraceae › Antimicrobial guaianolide sesquiterpenoids...
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Tests de sensibilité microbienne › Antimicrobial guaianolide sesquiterpenoids...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Antimicrobial guaianolide sesquiterpenoids...
questionsmedicales.fr › Facteurs biologiques › Composés phytochimiques › Antimicrobial guaianolide sesquiterpenoids...
questionsmedicales.fr › Structures de plante › Parties aériennes de plante › Feuilles de plante › Antimicrobial guaianolide sesquiterpenoids...
questionsmedicales.fr › Eucaryotes › Plantes › Plantes médicinales › Antimicrobial guaianolide sesquiterpenoids...
questionsmedicales.fr › Régions géographiques › Asie › Asie de l'Ouest › Moyen Orient › Arabie saoudite › Antimicrobial guaianolide sesquiterpenoids...
questionsmedicales.fr › Composés polycycliques › Sesquiterpènes polycycliques › Sesquiterpènes de type eudesmane › Sesquiterpènes de type guaïane › Antimicrobial guaianolide sesquiterpenoids...