Genome-wide association meta-analysis of functional outcome after ischemic stroke.
Journal
Neurology
ISSN: 1526-632X
Titre abrégé: Neurology
Pays: United States
ID NLM: 0401060
Informations de publication
Date de publication:
19 03 2019
19 03 2019
Historique:
received:
06
07
2018
accepted:
09
11
2018
pubmed:
24
2
2019
medline:
18
12
2019
entrez:
24
2
2019
Statut:
ppublish
Résumé
To discover common genetic variants associated with poststroke outcomes using a genome-wide association (GWA) study. The study comprised 6,165 patients with ischemic stroke from 12 studies in Europe, the United States, and Australia included in the GISCOME (Genetics of Ischaemic Stroke Functional Outcome) network. The primary outcome was modified Rankin Scale score after 60 to 190 days, evaluated as 2 dichotomous variables (0-2 vs 3-6 and 0-1 vs 2-6) and subsequently as an ordinal variable. GWA analyses were performed in each study independently and results were meta-analyzed. Analyses were adjusted for age, sex, stroke severity (baseline NIH Stroke Scale score), and ancestry. The significance level was We identified one genetic variant associated with functional outcome with genome-wide significance (modified Rankin Scale scores 0-2 vs 3-6, In this large GWA study on functional outcome after ischemic stroke, we report one significant variant and several variants with suggestive association to outcome 3 months after stroke onset with plausible mechanistic links to poststroke recovery. Future replication studies and exploration of potential functional mechanisms for identified genetic variants are warranted.
Identifiants
pubmed: 30796134
pii: WNL.0000000000007138
doi: 10.1212/WNL.0000000000007138
pmc: PMC6511098
doi:
Types de publication
Journal Article
Meta-Analysis
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1271-e1283Subventions
Organisme : Medical Research Council
ID : MR/S004130/1
Pays : United Kingdom
Organisme : NIDDK NIH HHS
ID : P30 DK072488
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS100178
Pays : United States
Organisme : NINDS NIH HHS
ID : U01 NS069208
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2019 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.
Références
Brain Res Bull. 2012 Jan 4;87(1):50-9
pubmed: 22001340
Int J Mol Sci. 2017 Dec 22;19(1):
pubmed: 29271887
FEBS J. 2013 Jan;280(2):584-95
pubmed: 22360570
Acta Neuropathol. 2016 May;131(5):753-73
pubmed: 26932603
Curr Opin Neurol. 2012 Dec;25(6):682-8
pubmed: 23044515
Mol Cell Neurosci. 2003 Sep;24(1):117-29
pubmed: 14550773
Stroke. 2014 Apr;45(4):1064-8
pubmed: 24569814
Science. 1998 Oct 16;282(5388):468-71
pubmed: 9774272
Learn Mem. 2013 Sep 16;20(10):540-52
pubmed: 24042850
Arterioscler Thromb Vasc Biol. 2018 Apr;38(4):964-975
pubmed: 29472232
Neurosci Lett. 2012 Jan 6;506(1):1-6
pubmed: 22133807
Stroke. 2016 Mar;47(3):646-51
pubmed: 26839351
Science. 1997 Jul 4;277(5322):55-60
pubmed: 9204896
Brain Res Mol Brain Res. 2004 Nov 4;130(1-2):68-80
pubmed: 15519678
J Neurol Phys Ther. 2015 Jan;39(1):52-61
pubmed: 25415554
Stroke. 2009 Nov;40(11):3618-26
pubmed: 19762700
J Cell Biol. 2000 Oct 16;151(2):221-34
pubmed: 11038171
Stroke. 2016 Sep;47(9):2427-34
pubmed: 27515845
Cell. 1996 Dec 27;87(7):1171-80
pubmed: 8980224
Gigascience. 2015 Feb 25;4:7
pubmed: 25722852
Nat Genet. 2017 Jan;49(1):131-138
pubmed: 27918535
Nucleic Acids Res. 2015 Jan;43(Database issue):D799-804
pubmed: 25428361
J Cereb Blood Flow Metab. 2009 Feb;29(2):385-97
pubmed: 18985053
J Hum Genet. 2016 Jun;61(6):547-53
pubmed: 26911352
Twin Res Hum Genet. 2015 Feb;18(1):86-91
pubmed: 25518859
Eur Stroke J. 2017 Sep;2(3):229-237
pubmed: 31008316
Neurobiol Dis. 2011 Jul;43(1):285-92
pubmed: 21515377
Bioinformatics. 2010 Sep 1;26(17):2190-1
pubmed: 20616382
J Cell Sci. 2014 Feb 1;127(Pt 3):641-52
pubmed: 24338367
Stem Cell Res. 2015 Nov;15(3):554-564
pubmed: 26473321
Proc Natl Acad Sci U S A. 2014 Oct 21;111(42):15226-31
pubmed: 25288737
Stem Cells. 2008 Aug;26(8):1973-84
pubmed: 18499893
Neurochem Res. 2011 Jan;36(1):67-75
pubmed: 20848190
Tohoku J Exp Med. 2011;224(3):221-8
pubmed: 21701128
Bioinformatics. 2014 Jun 15;30(12):i185-94
pubmed: 24931982
J Stroke Cerebrovasc Dis. 2011 Mar-Apr;20(2):134-44
pubmed: 20472470
PLoS One. 2014 Dec 03;9(12):e114156
pubmed: 25470006
Stroke. 1993 Jan;24(1):35-41
pubmed: 7678184
Front Aging Neurosci. 2014 Mar 18;6:44
pubmed: 24672479
Science. 2015 May 8;348(6235):648-60
pubmed: 25954001
PM R. 2010 Dec;2(12 Suppl 2):S241-52
pubmed: 21172686
Stroke. 2007 Apr;38(4):1384-6
pubmed: 17322093
Circ Res. 2000 Sep 1;87(5):370-7
pubmed: 10969034
Brain Res. 2013 Nov 6;1537:312-8
pubmed: 24035862