Molecular Imaging of the Glomerulus via Mesangial Cell Uptake of Radiolabeled Tilmanocept.
Animals
Dextrans
/ pharmacokinetics
Immunohistochemistry
Injections, Intravenous
Kidney Glomerulus
/ diagnostic imaging
Kinetics
Lectins, C-Type
/ metabolism
Liver
/ metabolism
Lymph Nodes
/ pathology
Male
Mannose Receptor
Mannose-Binding Lectins
/ metabolism
Mesangial Cells
/ metabolism
Mice
Microscopy, Fluorescence
Molecular Imaging
Positron-Emission Tomography
Radiopharmaceuticals
/ pharmacokinetics
Rats
Receptors, Cell Surface
/ metabolism
Sentinel Lymph Node Biopsy
Technetium Tc 99m Pentetate
/ analogs & derivatives
Tissue Distribution
Tomography, Emission-Computed, Single-Photon
Whole Body Imaging
68Ga-tilmanocept
99mTc-tilmanocept
kidney imaging
mesangial cells
Journal
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
ISSN: 1535-5667
Titre abrégé: J Nucl Med
Pays: United States
ID NLM: 0217410
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
26
11
2018
accepted:
24
01
2019
pubmed:
24
2
2019
medline:
14
4
2020
entrez:
24
2
2019
Statut:
ppublish
Résumé
An unmet need for the clinical management of chronic kidney disease is a predictive tool of kidney function during the first decade of the disease, when there is silent loss of glomerular function. The objective of this study was to demonstrate receptor-mediated binding of tilmanocept to CD206 within the kidney and provide evidence of kinetic sensitivity of this binding to renal function.
Identifiants
pubmed: 30796169
pii: jnumed.118.223727
doi: 10.2967/jnumed.118.223727
pmc: PMC6910642
doi:
Substances chimiques
Dextrans
0
Lectins, C-Type
0
Mannose Receptor
0
Mannose-Binding Lectins
0
Radiopharmaceuticals
0
Receptors, Cell Surface
0
gallium-diethylenetriaminepentaacetic acid-mannosyl-dextran
0
Technetium Tc 99m Pentetate
VW78417PU1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1325-1332Subventions
Organisme : NIDDK NIH HHS
ID : DP3 DK094352
Pays : United States
Organisme : NIBIB NIH HHS
ID : T32 EB005970
Pays : United States
Informations de copyright
© 2019 by the Society of Nuclear Medicine and Molecular Imaging.
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