Fracture status in middle-aged individuals with early CKD: cross-sectional analysis of the CARTaGENE survey.
Adult
Age Distribution
Aged
Calcaneus
/ diagnostic imaging
Cross-Sectional Studies
Female
Glomerular Filtration Rate
Health Surveys
Humans
Male
Middle Aged
Osteoporotic Fractures
/ diagnostic imaging
Prevalence
Quebec
/ epidemiology
Renal Insufficiency, Chronic
/ complications
Severity of Illness Index
Ultrasonography
CARTaGENE
Chronic kidney disease
Fracture
Journal
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
ISSN: 1433-2965
Titre abrégé: Osteoporos Int
Pays: England
ID NLM: 9100105
Informations de publication
Date de publication:
Apr 2019
Apr 2019
Historique:
received:
02
11
2018
accepted:
12
02
2019
pubmed:
24
2
2019
medline:
18
12
2019
entrez:
24
2
2019
Statut:
ppublish
Résumé
Whether early chronic kidney disease (CKD) is associated with fracture in middle-aged adults is unclear. In a cross-sectional analysis of the CARTaGENE survey, we observed that early CKD was not associated with increased fracture, did not modify the association between calcaneal QUS and fracture, but modified the association between clinical, pharmacological parameters and fracture. The association between advanced CKD and increased fracture risk is well described. However, whether early CKD is associated with increased fractures, especially in middle-aged adults, is unclear. We aimed to assess if early CKD is associated with increased fracture status and whether early CKD status modifies the association between calcaneal quantitative ultrasound parameters, clinical, pharmacological parameters, and fractures. Cross-sectional analysis of CARTaGENE, a population-based survey of 40- to 69-year-old individuals. Individuals with CKD (stage 2, estimated glomerular filtration rate [eGFR] 60-89 ml/min/1.73 m A total of 17,608 individuals (656 CKD stage 3; 8227 stage 2; 8725 non-CKD) were included. CKD stage 2 and 3 individuals (mean eGFR 78 and 53 ml/min/1.73 m CKD stage 3 was not associated with an increase in fracture status. QUS parameters were similarly associated with fracture status in patients with and without CKD.
Identifiants
pubmed: 30796539
doi: 10.1007/s00198-019-04902-1
pii: 10.1007/s00198-019-04902-1
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
787-795Subventions
Organisme : Fonds de Recherche du Qu?bec - Sant?
ID : 32661
Organisme : Kidney Foundation of Canada
ID : KFOC160013
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