Identification of two new core chromosome-encoded superantigens in Streptococcus pyogenes; speQ and speR.
Group A Streptococcus
Mitogen
Scarlet fever
Streptococcus pyogenes
Superantigens
Toxic shock syndrome
Journal
The Journal of infection
ISSN: 1532-2742
Titre abrégé: J Infect
Pays: England
ID NLM: 7908424
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
12
11
2018
revised:
25
01
2019
accepted:
17
02
2019
pubmed:
24
2
2019
medline:
18
6
2020
entrez:
24
2
2019
Statut:
ppublish
Résumé
Superantigens are ubiquitous within the Streptococcus pyogenes genome, which suggests that superantigen-mediated T-cell activation provides a significant selective advantage. S. pyogenes can carry a variable complement of the 11 known superantigens. We have identified two novel S. pyogenes superantigens, denoted speQ and speR, adjacent to each other in the core-chromosome of isolates belonging to eleven different emm-types. Although distinct from other superantigens, speQ and speR were most closely related to speK and speJ, respectively. Recombinant SPEQ and SPER were mitogenic towards human peripheral blood mononuclear cells at ng/ml concentrations, and SPER was found to be more mitogenic than SPEQ.
Identifiants
pubmed: 30796950
pii: S0163-4453(19)30054-4
doi: 10.1016/j.jinf.2019.02.005
pii:
doi:
Substances chimiques
Antigens, Bacterial
0
Mitogens
0
Superantigens
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
358-363Subventions
Organisme : Medical Research Council
ID : G0800777
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_12015
Pays : United Kingdom
Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.