DNA (Hydroxy)Methylation in T Helper Lymphocytes.

Animals DNA / chemistry DNA Methylation Humans T-Lymphocytes, Helper-Inducer / metabolism

Journal

Trends in biochemical sciences
ISSN: 0968-0004
Titre abrégé: Trends Biochem Sci
Pays: England
ID NLM: 7610674

Informations de publication

Date de publication:
07 2019
Historique:
received: 30 11 2018
revised: 22 01 2019
accepted: 25 01 2019
pubmed: 25 2 2019
medline: 18 9 2020
entrez: 25 2 2019
Statut: ppublish

Résumé

Upon recognition of an antigen, the differentiation of antigen-inexperienced naïve T lymphocytes into subsets able to effectively coordinate host defense is controlled by a network of transcription factors and regulatory molecules. In the cell nucleus, these factors act in the context of epigenetic modifications that influence DNA accessibility and ultimately gene expression. This review discusses recent findings about the role of DNA methylation (and its oxidized derivatives) in modulating the differentiation and functions of T helper lymphocytes of the adaptive immune system.

Identifiants

DOI: 10.1016/j.tibs.2019.01.009 PMID: 30797629
pubmed: 30797629
pii: S0968-0004(19)30018-0
doi: 10.1016/j.tibs.2019.01.009
pii:
doi:

Substances chimiques

DNA 9007-49-2

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

589-598

Subventions

Organisme : Swiss National Science Foundation
ID : 156875
Pays : Switzerland

Informations de copyright

Copyright © 2019 Elsevier Ltd. All rights reserved.

Auteurs

Silvia Monticelli (S)

Institute for Research in Biomedicine and Università della Svizzera italiana, Via Vincenzo Vela 6, CH-6500 Bellinzona, Switzerland. Electronic address: silvia.monticelli@irb.usi.ch.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › DNA (Hydroxy)Methylation in T Helper Lymphocytes.
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ADN › DNA (Hydroxy)Methylation in T Helper Lymphocytes.
questionsmedicales.fr › Phénomènes génétiques › Méthylation de l'ADN › DNA (Hydroxy)Methylation in T Helper Lymphocytes.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › DNA (Hydroxy)Methylation in T Helper Lymphocytes.
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T auxiliaires › DNA (Hydroxy)Methylation in T Helper Lymphocytes.